{"title":"A simple two-transition model for loss of infectivity of phages on exposure to organic solvent","authors":"Teruhiko Matsubara , Wakako Emoto , Katsuhiro Kawashiro","doi":"10.1016/j.bioeng.2007.02.002","DOIUrl":null,"url":null,"abstract":"<div><p>The effect of water-miscible organic solvents on the stability of filamentous phages displaying a random peptide library was investigated. A kinetic analysis of the time course of viral infectivity indicated that the transition between the noninfectious and infectious form was directly related to the concentration of organic solvent.</p></div>","PeriodicalId":80259,"journal":{"name":"Biomolecular engineering","volume":"24 2","pages":"Pages 269-271"},"PeriodicalIF":0.0000,"publicationDate":"2007-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bioeng.2007.02.002","citationCount":"10","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomolecular engineering","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1389034407000214","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 10
Abstract
The effect of water-miscible organic solvents on the stability of filamentous phages displaying a random peptide library was investigated. A kinetic analysis of the time course of viral infectivity indicated that the transition between the noninfectious and infectious form was directly related to the concentration of organic solvent.
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