Gene expression in low glycemic index diet - impact on metabolic control.

Forum of Nutrition Pub Date : 2007-01-01 DOI:10.1159/000107089

Eiji Takeda, Hidekazu Arai, Kazusa Muto, Kaoru Matsuo, Masae Sakuma, Makiko Fukaya, Hisami Yamanaka-Okumura, Hironori Yamamoto, Yutaka Taketani

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引用次数: 8

Abstract

Background: Correcting postprandial hyperglycemia forms an important part of the prevention and management of type 2 diabetes.

Methods: A low-glycemic-index liquid formula designated as Inslow was prepared by replacing dextrin in the standard balanced formula (SBF) with 55.7% palatinose. Long-term administration of Inslow prevented fatty liver and improved insulin resistance in rats. Expressions of mRNA of factors involved in glucose and lipid metabolism were determined to clarify its mechanism.

Results: Analysis of mRNA expressions revealed that Inslow increased the expression of enzymes involved in Beta -oxidation and peroxisome proliferator-activated receptor-alpha (PPAR-alpha) in the liver, and increased PPAR-gamma, adiponectin and uncoupling protein 2 as well as decreased tumor necrosis factor alpha in adipose tissue in comparison with those of SBF.

Conclusions: Inslow may induce improvement of insulin resistance by accelerated Beta-oxidation through increased expression of the hepatic PPAR-alpha gene and adipocyte PPAR-gamma gene. Therefore, Inslow is a functional food which prevents and treats type 2 diabetes.

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低血糖指数饮食中基因表达对代谢控制的影响。

背景:纠正餐后高血糖是2型糖尿病预防和治疗的重要组成部分。方法:用55.7%的巴氏糖代替标准平衡配方中的糊精，制备低血糖指数液体配方Inslow。长期给药Inslow可预防大鼠脂肪肝，改善胰岛素抵抗。通过检测糖脂代谢相关因子mRNA的表达来阐明其机制。结果:mRNA表达分析显示，与SBF相比，Inslow增加了肝脏中β -氧化和过氧化物酶体增殖激活受体α (ppar - α)相关酶的表达，增加了脂肪组织中ppar - γ、脂联素和解偶联蛋白2的表达，降低了肿瘤坏死因子α的表达。结论:Inslow可能通过增加肝脏ppar - α基因和脂肪细胞ppar - γ基因的表达，通过加速β -氧化诱导胰岛素抵抗的改善。因此，Inslow是预防和治疗2型糖尿病的功能性食品。

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Forum of Nutrition

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