Mother Nature's gifts to diseases of man: the impact of natural products on anti-infective, anticholestemics and anticancer drug discovery.

Mark S Butler, David J Newman
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引用次数: 59

Abstract

This chapter is designed to demonstrate that compounds derived from nature are still in the forefront of drug discovery in diseases such as microbial and parasitic infections, carcinomas of many types and control of cholesterol/lipids in man. In each disease area we have provided short discussions of past, present and future agents, in general only considering compounds currently in clinical Phase II or later, that were/are derived from nature's chemical skeletons. Finishing with a discussion of the current and evolving role(s) of microbes (bacteria and fungi) in the production of old and new agents ostensibly produced by higher organisms.

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大自然给人类疾病的礼物:天然产物对抗感染、抗胆碱和抗癌药物发现的影响。
本章的目的是证明,从自然界中提取的化合物仍然处于疾病药物发现的前沿,如微生物和寄生虫感染,多种类型的癌症和控制人的胆固醇/脂质。在每个疾病领域,我们对过去、现在和未来的药物进行了简短的讨论,一般只考虑目前处于临床II期或之后的化合物,这些化合物是从自然界的化学骨架中提取的。最后讨论微生物(细菌和真菌)在生产表面上由高等生物生产的新旧制剂中的当前和不断发展的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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