Migration, cell-cell interaction and adhesion in the immune system.

M Gunzer
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引用次数: 12

Abstract

Migration is an essential function of immune cells. It is necessary to lead immune cell precursors from their site of generation to the places of maturation or function. Cells of the adaptive immune system also need to interact physically with each other or with specialized antigen presenting cells in lymphatic tissues in order to become activated. Thereby a complex series of controlled migration events, adhesive interactions and signalling responses is induced. Finally cells must be able to leave the activating tissues and re-enter the bloodstream from which they extravasate into inflamed tissue sites. Cells of the innate immune system can function directly without the need for previous activation. However, these cells have to adapt their function to a panoply of pathogens and environmental niches which can be invaded. The current review highlights the central aspects of cellular dynamics underlying adaptive and innate cellular immunity. Thereby a focus will be put on recent results obtained by microscopic observation of live cells in vitro or by intravital 2-photon microscopy in live animals.

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免疫系统中的迁移、细胞间相互作用和粘附。
迁移是免疫细胞的一项基本功能。有必要将免疫细胞前体从其产生部位引导到成熟或起作用的部位。适应性免疫系统的细胞也需要相互作用,或者与淋巴组织中的特殊抗原呈递细胞相互作用,才能被激活。因此,一系列复杂的受控迁移事件、粘附相互作用和信号反应被诱导。最后,细胞必须能够离开激活组织并重新进入血流,从血流中渗出到发炎的组织部位。先天免疫系统的细胞不需要事先激活就能直接起作用。然而,这些细胞必须调整它们的功能,以适应可能被入侵的病原体和环境生态位。当前的回顾强调了细胞动力学的核心方面,潜在的适应性和先天细胞免疫。因此,重点将放在通过体外活细胞的显微观察或活体动物的活体双光子显微镜获得的最新结果上。
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