[Radiation-induced chromosome aberrations].

Abstract

Chromosomal aberrations in peripheral lymphocytes have been used as biomarkers of radiation exposure. The results obtained for this cytogentic study suggest that 86 persons who examined were with structural chromosome aberrations. The sample was included 100 persons who were exposed to radiation professionally. The most frequent persons were found with one, two, three and four chromosome aberrations, and 19 persons had six and more aberrations, while 341 total chromosome aberrations were registried. The most frequent radiation-induced chromosome aberrations in vivo were chromatid breaks, acentric fragments, acentric minutes and isochromatid breaks, while dicentrics, rings, quadriradials and triradials, translocations (chromosome rearrangements), marker chromosomes and chromosome repulsions were less frequent. These results suggest that are the most frequent chromosome single breaks, while more complex recombinations are less frequent. Obtained results when compared with results of standard showed that 32.56% of total number of persons with aberrations or 28% total number of analyzed persons found was different from standard. Chromosomal aberrations in lymphocytes suggest that these persons were probably exposed to ionizing radiation.