Opportunities for collaborative phenotyping for disease resistance traits in a large beef cattle resource population.

R M Thallman, L A Kuehn, M F Allan, G L Bennett, M Koohmaraie
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引用次数: 5

Abstract

The Germplasm Evaluation (GPE) Project at the US Meat Animal Research Center (USMARC) is planned to produce about 3,000 calves per year in support of the following objectives: identification and validation of genetic polymorphisms related to economically relevant traits (ERT), estimation of breed and heterosis effects among 16 breeds for ERT, and estimation of genetic correlations among ERT and physiological indicator traits (PIT). Opportunities exist for collaboration in the development and collection of PIT phenotypes for disease resistance. Other areas of potential collaboration include detailed diagnosis (identification of disease causing organisms, etc.) of treated animals, collaborative development of epidemiological statistical models that would extract more information from the records of diagnoses and treatments, or pharmacogenetics. Concentrating a variety of different phenotypes and research approaches on the same population makes each component much more valuable than it would be individually.

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在大型肉牛资源群体中进行抗病性状合作表型分析的机会。
美国肉类动物研究中心(USMARC)的种质评估(GPE)项目计划每年生产约3000头小牛,以支持以下目标:鉴定和验证与经济相关性状(ERT)相关的遗传多态性,估计16个ERT品种的品种和杂种优势效应,以及估计ERT与生理指标性状(PIT)之间的遗传相关性。在开发和收集用于抗病的PIT表型方面存在合作机会。其他潜在的合作领域包括治疗动物的详细诊断(确定致病生物体等),合作开发流行病学统计模型,从诊断和治疗记录中提取更多信息,或药物遗传学。将各种不同的表型和研究方法集中在同一个群体上,使得每个组成部分比单独的组成部分更有价值。
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