Automated synthesis of radiopharmaceuticals for positron emission tomography: an apparatus for [1-C] labeled carboxylic acid.

K Yajima, H Yamazaki, H Kawashima, S Ino, N Hayashi, Y Miyake
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引用次数: 5

Abstract

A fully automated apparatus for the synthesis and formulation of short-lived (11)C (t(1/2) = 20 min)-labeled carboxylic acids for positron emission tomograpy (PET) has been developed. Injectable solutions of [1-(11)C]acetic acid, [1-(11)C]octanoic acid and [1-(11)C]palmitic acid wilh radioactivities of 6.36-8.29 GBq, 0.070-1.43 GBq and 0.42-0.89 GBq were obtained. The preparation time was under 40 min after the end of bombardment. An automatic washing function means that labeled compound of the same or different kinds can be produced several times a day without any maintenance of the system. The control system is sited away from the 'hot laboratory', so operator exposure to radiation is minimized.

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用于正电子发射断层扫描的放射性药物的自动合成:[1-C]标记羧酸的装置。
研制了一种用于合成和配制短寿命(11)C (t(1/2) = 20 min)标记羧酸的全自动装置,用于正电子发射断层扫描(PET)。得到了[1-(11)C]乙酸、[1-(11)C]辛酸和[1-(11)C]棕榈酸的可注射溶液,其放射性分别为6.36 ~ 8.29 GBq、0.070 ~ 1.43 GBq和0.42 ~ 0.89 GBq。轰炸结束后,准备时间不到40分钟。自动洗涤功能意味着相同或不同种类的标记化合物可以一天生产几次,而无需对系统进行任何维护。控制系统位于远离“热实验室”的地方,因此操作人员暴露于辐射的程度被降到最低。
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