Platelet serotonin concentration and monoamine oxidase activity in hypothyroid patients.

Hormone research Pub Date : 2009-01-01 Epub Date: 2009-03-04 DOI:10.1159/000201109

Tamara Stipcevic, Sanja Kusacic-Kuna, Martina Dezeljin, Damir Dodig, Mirko Korsic, Nela Pivac, Dorotea Muck-Seler

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引用次数: 10

Abstract

Background/aim: The relationship between the hypothalamic-pituitary-thyroid (HPT) axis and the serotonergic (5-hydroxytryptamine, 5-HT) system is not clear. The aim of the study was to determine platelet biochemical markers (5-HT concentration and monoamine oxidase B, MAO-B, activity) in hypothyroid patients.

Methods: The study included 25 medication-free female hypothyroid patients in postoperative follow-up after total thyroidectomy due to papillary thyroid carcinoma, who had not been treated with synthetic thyroxine (T(4)) for 4 weeks, and 44 age-matched euthyroid healthy women. The platelet 5-HT concentration, platelet MAO-B activity, total T(4) and thyroid-stimulating hormone (TSH) levels were determined using spectrofluorimetric methods, radioimmunoassay and fluoroimmunoassay, respectively.

Results: Hypothyroid patients had significantly higher TSH, significantly lower T(4) levels and platelet 5-HT concentrations, and unchanged platelet MAO-B activity than healthy subjects. A positive correlation was found between the 5-HT concentration and platelet MAO-B activity, and between the platelet MAO-B activity and T(4) in control subjects.

Conclusions: Reduced platelet 5-HT concentrations in hypothyroid patients suggests a complex interaction between the 5-HT system and HPT axis activity, which could be related to the frequent occurrence of depressive symptoms in hypothyroid patients. The determination of platelet 5-HT concentrations should be considered a diagnostic tool for the evaluation of depressive symptoms in hypothyroid patients during the hormone withdrawal procedure.

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甲状腺功能减退患者血小板血清素浓度与单胺氧化酶活性的关系。

背景/目的:下丘脑-垂体-甲状腺(HPT)轴与血清素能(5-羟色胺，5-HT)系统之间的关系尚不清楚。方法:本研究纳入25例甲状腺乳头状癌全甲状腺切除术术后随访的未使用合成甲状腺素(T(4))治疗4周的无药物治疗的女性甲状腺功能减退患者，以及44例年龄匹配的甲状腺功能正常的健康女性。结论:甲状腺功能减退患者血小板5-HT浓度降低提示5-HT系统与HPT轴活性之间存在复杂的相互作用，这可能与甲状腺功能减退患者抑郁症状的多发有关。血小板5-羟色胺浓度的测定应被认为是评估甲状腺功能减退患者在激素停药过程中抑郁症状的诊断工具。

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Hormone research 医学-内分泌学与代谢

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