Enhancement of Cognitive and Electrophysiological Measures of Hippocampal Functioning in Rats by a Low, But Not High, Dose of Dehydroepiandrosterone Sulfate (DHEAS).

Nonlinearity in biology, toxicology, medicine Pub Date : 2004-10-01 DOI:10.1080/15401420490900290

David M Diamond

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引用次数: 5

Abstract

Dehydroepiandrosterone sulfate (DHEAS) is a steroid hornone that is synthesized, de novo, in the brain. Endogenous DHEAS levels correlate with the quality of mental and physical health, where the highest levels of DHEAS occur in healthy young adults and reduced levels of DHEAS are found with advanced age, disease, or extreme stress. DHEAS supplementation, therefore, may serve as a therapeutic agent against a broad range of maladies. This paper summarizes laboratory findings on dose-response relationships between DHEAS and cognitive and electrophysiological measures of hippocampal functioning. It was found that a low, but not a high, dose of DHEAS enhanced hippocampal primed burst potentiation (a physiological model of memory) as well as spatial (hippocampal-dependent) memory in rats. This complex dose-response function of DHEAS effects on the brain and memory may contribute toward the inconsistent findings that have been obtained by other investigators in studies on DHEAS administration in people.

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低剂量而非高剂量硫酸脱氢表雄酮(DHEAS)增强大鼠海马功能的认知和电生理测量。

硫酸脱氢表雄酮(DHEAS)是一种类固醇激素，在大脑中从头合成。内源性DHEAS水平与精神和身体健康的质量相关，其中DHEAS水平最高的是健康的年轻人，而DHEAS水平降低的是老年人、疾病或极端压力。因此，DHEAS补充剂可以作为治疗多种疾病的药物。本文综述了DHEAS与海马功能认知和电生理测量之间的剂量-反应关系的实验室研究结果。研究发现，低剂量而非高剂量的DHEAS可增强大鼠的海马启动脉冲增强(一种记忆的生理模型)和空间记忆(海马依赖)。DHEAS对大脑和记忆影响的这种复杂的剂量-反应函数可能导致其他研究人员在DHEAS对人的应用研究中获得的结果不一致。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Nonlinearity in biology, toxicology, medicine

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