Abnormal expression of fibroblast growth factor receptor on lens epithelial cells by dexamethasone: implications for glucocorticoid-induced posterior subcapsular cataract.

Annals of ophthalmology Pub Date : 2009-01-01
Baichuan Wang, Chunlin Chen, Xiaolei Yin, Xiaofan Chen, Jian Ye
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引用次数: 0

Abstract

We investigated glucocorticoids-induced alteration of bFGF in AqH, FGFR and beta-crystallin in rat lens epithelial cells (LECs). Results. Data showed dexamethasone had no effect on bFGF in AqH, but reduced FGFR1 in LECs. After six months treatment, cells were detected under posterior capsule in 4/12 lenses. In vitro observations revealed a down-regulated FGFR1 or beta-crystallin by dexamethasone. FGFR in LECs may play an important role in formation of glucocorticoid-induced PSC.

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地塞米松对晶状体上皮细胞成纤维细胞生长因子受体的异常表达:糖皮质激素诱导的后囊膜下白内障的意义。
我们研究了糖皮质激素诱导大鼠晶状体上皮细胞(LECs)中AqH中bFGF、FGFR和β -晶体蛋白的改变。结果。数据显示,地塞米松对AqH中的bFGF没有影响,但会降低LECs中的FGFR1。治疗6个月后,4/12晶状体后囊膜下检测到细胞。体外观察显示FGFR1或β -结晶蛋白被地塞米松下调。LECs中的FGFR可能在糖皮质激素诱导的PSC形成中发挥重要作用。
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Annals of ophthalmology
Annals of ophthalmology 医学-眼科学
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