[Antituberculosis humoral immunity in patients with tuberculosis, HIV infection concurrent with tuberculoses].

I M Khaertynova, A P Tsybul'kin, R Sh Valiev, G A Idiiatullina, S E Romanenko
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Abstract

Enzyme immunoassay (EIA) was used to study the diagnostic value of PTAT circulating in the free and attached state as part of serum circulating immune complexes (CIC) in 34 patients with tuberculosis (TB), 38 with concomitant HIV/TB infection, and 92 with HIV infection without active tuberculosis. A humoral immunological response as circulating PTAT and PTAT conjugated in specific CIC depends on both the form and degree of pulmonary tuberculosis and may be employed to diagnose a disease running as both an independent entity and in the concomitant HIV/TB infection. The use of specific CIC yields additional information on the presence and circulation of mycobacterial antigenic components, which should be borne in mind at the early stages of the disease. EIA diagnosis of pulmonary tuberculosis from the significant titer of PTAT is relatively effective at the stages with infiltration and it ascertains destructive changes before their detection on X-ray and tomographic films.

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[结核病患者的抗结核体液免疫,艾滋病毒感染合并结核病]。
采用酶免疫分析法(EIA)对34例结核病(TB)患者、38例合并HIV/TB感染患者和92例未合并活动性结核的HIV感染患者进行血清循环免疫复合物(CIC)游离和附着状态PTAT的诊断研究。体液免疫反应如循环PTAT和特异性CIC中结合PTAT取决于肺结核的形式和程度,可用于诊断作为独立实体运行的疾病和伴随的HIV/TB感染。使用特定CIC可获得关于分枝杆菌抗原性成分存在和循环的额外信息,在疾病的早期阶段应牢记这一点。PTAT显著滴度对肺结核的EIA诊断在浸润阶段相对有效,在x线和断层扫描前确定其破坏性变化。
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[Vaccine prophylaxis of tuberculosis: implication and problems]. [Prevalence of tuberculosis among children and adolescents in the Russian Federation: analysis of official statistics]. [Analysis of the rates of infection and incidence of tuberculosis in children from a poor epidemic-situation area in 2001 to 2006]. [Clinical and epidemiological features of tuberculosis ostitis in BCG-vaccinated children]. [Detection of tuberculosis in Moscow adolescents].
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