The role of the DLPFC in inductive reasoning of MCI patients and normal agings: an fMRI study.

YanHui Yang, PeiPeng Liang, ShengFu Lu, KunCheng Li, Ning Zhong
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引用次数: 42

Abstract

Previous studies of young people have revealed that the left dorsolateral prefrontal cortex (DLPFC) plays an important role in inductive reasoning. An fMRI experiment was performed in this study to examine whether the left DLPFC was involved in inductive reasoning of MCI patients and normal aging, and whether the activation pattern of this region was different between MCI patients and normal aging. The fMRI results indicated that MCI patients had no difference from normal aging in behavior performance (reaction time and accuracy) and the activation pattern of DLPFC. However, the BOLD response of the DLPFC region for MCI patients was weaker than that for normal aging, and the functional connectivity between the bilateral DLPFC regions for MCI patients was significantly higher than for normal aging. Taken together, these results indicated that DLPFC plays an important role in inductive reasoning of aging, and the functional abnormity of DLPFC may be an earlier marker of MCI before structural alterations.

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DLPFC在MCI患者和正常衰老的归纳推理中的作用:一项fMRI研究。
先前对年轻人的研究表明,左背外侧前额叶皮层(DLPFC)在归纳推理中起着重要作用。本研究通过fMRI实验研究了MCI患者的左DLPFC是否参与归纳推理和正常衰老,以及该区域的激活模式在MCI患者和正常衰老之间是否存在差异。fMRI结果显示,MCI患者在行为表现(反应时间和准确性)和DLPFC的激活模式上与正常衰老患者没有差异。然而,MCI患者DLPFC区域的BOLD反应弱于正常衰老,MCI患者双侧DLPFC区域之间的功能连通性明显高于正常衰老。综上所述,这些结果表明DLPFC在衰老的归纳推理中起着重要作用,DLPFC的功能异常可能是结构改变前MCI的早期标志。
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