9-(2-C-Cyano-2-deoxy-beta-D-arabino-pentofuranosyl)guanine, a potential antitumor agent against B-lymphoma infected with Kaposi's sarcoma-associated herpesvirus.

Satoshi Ichikawa, Masaki Otawa, Yasuhiro Teishikata, Koji Yamada, Masahiro Fujimuro, Hideyoshi Yokosawa, Akira Matsuda
{"title":"9-(2-C-Cyano-2-deoxy-beta-D-arabino-pentofuranosyl)guanine, a potential antitumor agent against B-lymphoma infected with Kaposi's sarcoma-associated herpesvirus.","authors":"Satoshi Ichikawa,&nbsp;Masaki Otawa,&nbsp;Yasuhiro Teishikata,&nbsp;Koji Yamada,&nbsp;Masahiro Fujimuro,&nbsp;Hideyoshi Yokosawa,&nbsp;Akira Matsuda","doi":"10.1093/nass/nrp048","DOIUrl":null,"url":null,"abstract":"<p><p>Several 9-(2-C-cyano-2-deoxy-l-beta-D-arabino-pentofuranosyl)purine derivatives were tested against Kaposi's sarcoma-associated herpesvirus (KSHV)-infected primary effusion lymphoma (PEL) cells. The guanine derivative (2, CNDAG) as well as the 2-amino-6-substituted-purine derivatives 3, 4 and 5 inhibited KSHV-positive cell growth but showed no cytotoxicity against KSHV-negative cells at >15 muM concentrations. Therefore, it was found that compounds 2, 3, 4 and 5 showed selective cytotoxicity against PEL cells infected with KSHV.</p>","PeriodicalId":87448,"journal":{"name":"Nucleic acids symposium series (2004)","volume":" 53","pages":"95-6"},"PeriodicalIF":0.0000,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1093/nass/nrp048","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nucleic acids symposium series (2004)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1093/nass/nrp048","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2

Abstract

Several 9-(2-C-cyano-2-deoxy-l-beta-D-arabino-pentofuranosyl)purine derivatives were tested against Kaposi's sarcoma-associated herpesvirus (KSHV)-infected primary effusion lymphoma (PEL) cells. The guanine derivative (2, CNDAG) as well as the 2-amino-6-substituted-purine derivatives 3, 4 and 5 inhibited KSHV-positive cell growth but showed no cytotoxicity against KSHV-negative cells at >15 muM concentrations. Therefore, it was found that compounds 2, 3, 4 and 5 showed selective cytotoxicity against PEL cells infected with KSHV.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
9-(2- c -氰-2-脱氧- β -d -阿拉伯-戊呋喃基)鸟嘌呤,一种潜在的抗卡波西肉瘤相关疱疹病毒感染b淋巴瘤的抗肿瘤药物。
研究了几种9-(2- c -氰-2-脱氧-l- β -d -阿拉伯戊呋喃基)嘌呤衍生物对卡波西肉瘤相关疱疹病毒(KSHV)感染的原发性积液淋巴瘤(PEL)细胞的抑制作用。鸟嘌呤衍生物(2、CNDAG)以及2-氨基-6-取代嘌呤衍生物3、4和5抑制kshv阳性细胞的生长,但在>15 muM浓度下对kshv阴性细胞无细胞毒性。因此,化合物2、3、4和5对感染KSHV的PEL细胞具有选择性细胞毒性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Chemical methods to study protein-nucleic acid interactions. Development of novel chemical probes to detect abasic sites in DNA. Assessment of the DNA damage using the fluorescence microscope. Exciton-controlled fluorescence: application to hybridization-sensitive fluorescent DNA probe. Multiple activities of c-di-GMP in Pseudomonas aeruginosa.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1