Cationic comb-type copolymer as a nucleic acid chaperone for DNA quadruplex.

Rui Moriyama, Naohiko Shimada, Arihiro Kano, Atsushi Maruyama
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引用次数: 1

Abstract

The intermolecular DNA quadruplex is attractive materials for design of nanomolecular constructs and machines. This folding kinetics is, however, slow, hampering its application to these materials. We have reported that the cationic comb-type copolymer accelerated duplex and triplex formation. In this study, the effect of the copolymer on the intermolecular quadruplex folding was investigated. The copolymer was found to accelerate the association of intermolecular quadruplex by three-orders. Furthermore, the copolymer induced the strand exchange reaction between intermolecular quadruplex and its single-stranded counterparts. We suggested that the copolymer acts as a nucleic acid chaperone for the intermolecular quadruplex.

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阳离子梳型共聚物作为DNA四重体的核酸伴侣。
分子间DNA四重体是设计纳米分子结构和机器的有吸引力的材料。然而,这种折叠动力学很慢,阻碍了它在这些材料上的应用。我们已经报道了阳离子梳型共聚物加速了双相和三相的形成。在本研究中,研究了共聚物对分子间四重折叠的影响。发现该共聚物能促进分子间四联体的三阶缔合。此外,共聚物诱导了分子间四链物和单链物之间的链交换反应。我们认为共聚物作为分子间四重体的核酸伴侣。
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