Photoinduced electron transfer reaction in diaminostilbene-tethered DNA duplexes.

Takeo Ito, Aiko Hayashi, Tsukasa Uchida, Kazuhito Tanabe, Hisatsugu Yamada, Sei-Ichi Nishimoto
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Abstract

DNA duplexes containing diaminostilbene (DAS) as a photoinduced electron donor were synthesized to investigate mechanisms of electron injection into DNA and the succeeding electron transfer in the duplexes. DAS-Capped hairpin DNA showed a high structural stability thereby attains large interaction between DAS and the terminal base pair. DAS-Tethered DNA by a single linker at the end of the duplex was also synthesized and the yields of photoinduced electron transfer through mismatched base pairs were quantified. Both duplexes showed similar electron transfer efficiencies depending on the base pairs, which suggests DAS stacks well on the "pi-way" of the duplex DNA.

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二氨基二苯乙烯链DNA双链的光诱导电子转移反应。
合成了以二氨基二苯乙烯(DAS)为光致电子供体的DNA双链体,研究了电子注入DNA和电子转移的机制。DAS- cap发夹DNA具有较高的结构稳定性,从而实现了DAS与末端碱基对之间的大相互作用。通过双链末端的单个连接体合成了DAS-Tethered DNA,并定量了通过不匹配碱基对引起的光诱导电子转移的产率。根据碱基对的不同,两种双链都显示出相似的电子转移效率,这表明DAS在双链DNA的“pi-way”上堆叠得很好。
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