The efficacy and safety of two fixed combinations: timolol-dorzolamide-brimonidine versus timolol-dorzolamide. A prospective, randomized, double-masked, multi-center, 6-month clinical trial.
Leopoldo Martín Baiza-Durán, Jaime Alvarez-Delgado, Angélica Yussett Contreras-Rubio, Javier Medrano-Palafox, Anel De Luca-Brown, Homero Casab-Rueda, Marco Antonio Cortés-Gastélum, Miguel Jorge Garcidueñas-Mejía, Pedro Gómez-Bastar, Félix Gil-Carrasco, Curt Hartleben-Matkin, Jesús Jiménez-Román, Miguel Luis Moreno-Marín, José Antonio Paczka-Zapata, Gustavo Velasco-Gallegos, Mario Vergara-Sinta
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Abstract
We compared the efficacy and safety of a new fixed combination of timolol 0.5%/odorzolamide 20%/brimonidine 0.2% in ophthalmic solution versus a fixed combination of timolol 0.5%/dorzolamide 2% in patients with open-angle glaucoma or ocular hypertension. The fixed triple combination was significantly more efficient in mean intraocular pressure reduction from baseline throughout the six-month follow-up.
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