The combination of selective inhibition of the cannabinoid CB1 receptor and activation of the cannabinoid CB2 receptor yields improved attenuation of motor and autonomic deficits in a mouse model of spinal cord injury.

Clinical neurosurgery Pub Date : 2009-01-01
Joshua E Heller, Darric E Baty, Ming Zhang, Hongbo Li, Martin Adler, Doina Ganea, John Gaughan, Christopher M Loftus, Jack I Jallo, Ronald F Tuma
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在脊髓损伤小鼠模型中,选择性抑制大麻素CB1受体和激活大麻素CB2受体的组合可改善运动和自主神经缺陷的衰减。
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