Endothelial progenitor cells: what use for the cardiologist?

Aurangzeb Siddique, Eduard Shantsila, Gregory Yh Lip, Chetan Varma
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引用次数: 40

Abstract

Endothelial Progenitor Cells (EPC) were first described in 1997 and have since been the subject of numerous investigative studies exploring the potential of these cells in the process of cardiovascular damage and repair. Whilst their exact definition and mechanism of action remains unclear, they are directly influenced by different cardiovascular risk factors and have a definite role to play in defining cardiovascular risk. Furthermore, EPCs may have important therapeutic implications and further understanding of their pathophysiology has enabled us to explore new possibilities in the management of cardiovascular disease. This review article aims to provide an overview of the vast literature on EPCs in relation to clinical cardiology.

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内皮祖细胞:心脏病专家有什么用?
内皮祖细胞(Endothelial Progenitor Cells, EPC)于1997年首次被描述,此后一直是许多调查研究的主题,探索这些细胞在心血管损伤和修复过程中的潜力。虽然它们的确切定义和作用机制尚不清楚,但它们直接受到不同心血管危险因素的影响,在确定心血管风险方面发挥着明确的作用。此外,内皮祖细胞可能具有重要的治疗意义,对其病理生理学的进一步了解使我们能够探索心血管疾病管理的新可能性。本文综述了EPCs与临床心脏病学相关的大量文献。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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