[Emergency colonic surgery: analysis of risk factors predicting morbidity and mortality].

Chirurgia italiana Pub Date : 2009-09-01
Gianluca Costa, Federico Tomassini, Simone Maria Tierno, Luigi Venturini, Barbara Frezza, Giulio Cancrini, Alessandro Mero, Luca Lepre
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Abstract

The aim of the present study was to identify risk factors for morbidity and mortality in patients submitted to emergency colonic surgery. Between 1997 and 2008 157 patients, 106 of whom affected by colon cancer (67.5%) and 51 by benign disease (32.5%), were treated. The risk factors for morbidity and mortality were evaluated by univariate and multivariate analysis considering clinical and demographic data. The overall 30-day morbidity and mortality rates were 19.1% (30 patients) and 12.7% (20 patients), respectively. Among patients affected by cancer the mortality rate was 15% (16 patients) and the morbidity rate 23.6% (25 patients), while among the patients with benign disease the mortality rate was 7.8% (4 patients) and the morbidity rate 9.8% (5 patients). No postoperative surgical complications were noted. The strongest risk factors for early death were postoperative medical complications such as cardiopulmonary, renal, thrombo-embolic and infectious complications. The results of the univariate analysis showed that advanced age, neoplastic disease, advanced stage of cancer and associated medical disease prior to surgery play a role as risk factors for morbidity and mortality. In the multivariate analysis only the presence of associated medical disease proved to be a significant independent predictor of outcome. Emergency surgery for both neoplastic and benign colonic disease is still associated with an increased risk of death. Although restorative colectomy should be regarded as the first choice procedure in the emergency setting, Hartmann's procedure is still widely used in high-risk patients.

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[紧急结肠手术:预测发病率和死亡率的危险因素分析]
本研究的目的是确定急诊结肠手术患者发病率和死亡率的危险因素。1997年至2008年期间,157名患者接受了治疗,其中106人患有结肠癌(67.5%),51人患有良性疾病(32.5%)。发病率和死亡率的危险因素通过单因素和多因素分析结合临床和人口统计数据进行评估。30天总发病率和死亡率分别为19.1%(30例)和12.7%(20例)。肿瘤患者死亡率为15%(16例),发病率为23.6%(25例);良性疾病患者死亡率为7.8%(4例),发病率为9.8%(5例)。术后无手术并发症。早期死亡的最大危险因素是术后并发症,如心肺、肾脏、血栓栓塞和感染并发症。单因素分析结果显示,高龄、肿瘤疾病、癌症晚期和术前相关内科疾病是发病率和死亡率的危险因素。在多变量分析中,只有相关医学疾病的存在被证明是结果的重要独立预测因子。肿瘤和良性结肠疾病的急诊手术仍然与死亡风险增加有关。虽然恢复性结肠切除术在紧急情况下应被视为首选手术,但Hartmann手术仍被广泛应用于高危患者。
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