{"title":"Nuclear receptor Rev-erbalpha: a heme receptor that coordinates circadian rhythm and metabolism.","authors":"Lei Yin, Nan Wu, Mitchell A Lazar","doi":"10.1621/nrs.08001","DOIUrl":null,"url":null,"abstract":"<p><p>Nuclear receptor Rev-erbalpha (NR1D1), previously considered to be an orphan nuclear receptor, is a receptor for heme, which promotes transcriptional repression via recruitment of the NCoR-HDAC3 corepressor complex. Rev-erbalpha gene regulation is circadian, and Rev-erbalpha comprises a critical negative limb of the core circadian clock by directly repressing the expression of the positive clock component, Bmal1. Rev-erbalpha also regulates the metabolic gene pathway, thus serving as a heme sensor for coordination of circadian and metabolic pathways.</p>","PeriodicalId":87415,"journal":{"name":"Nuclear receptor signaling","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2010-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1621/nrs.08001","citationCount":"137","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nuclear receptor signaling","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1621/nrs.08001","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 137
Abstract
Nuclear receptor Rev-erbalpha (NR1D1), previously considered to be an orphan nuclear receptor, is a receptor for heme, which promotes transcriptional repression via recruitment of the NCoR-HDAC3 corepressor complex. Rev-erbalpha gene regulation is circadian, and Rev-erbalpha comprises a critical negative limb of the core circadian clock by directly repressing the expression of the positive clock component, Bmal1. Rev-erbalpha also regulates the metabolic gene pathway, thus serving as a heme sensor for coordination of circadian and metabolic pathways.