T1 and T2 hypopharyngeal cancer treatment with laser microsurgery†

IF 1.9 3区医学 Q3 ONCOLOGY Journal of Surgical Oncology Pub Date : 2010-06-24 DOI:10.1002/jso.21550

Alexander D. Karatzanis MD, PhD, George Psychogios MD, PhD, Frank Waldfahrer MD, PhD, Johannes Zenk MD, PhD, Joachim Hornung MD, PhD, George A. Velegrakis MD, PhD, Heinrich Iro MD, PhD

{"title":"T1 and T2 hypopharyngeal cancer treatment with laser microsurgery†","authors":"Alexander D. Karatzanis MD, PhD, George Psychogios MD, PhD, Frank Waldfahrer MD, PhD, Johannes Zenk MD, PhD, Joachim Hornung MD, PhD, George A. Velegrakis MD, PhD, Heinrich Iro MD, PhD","doi":"10.1002/jso.21550","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background and Objective</h3>\n \n <p>To assess the oncologic results and functional outcomes of CO<sub>2</sub> laser microsurgery in T1 and T2 hypopharyngeal cancer.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>The files of 119 T1 and T2 hypopharyngeal carcinoma cases primarily managed with laser surgery were reviewed. Cases were assessed for 5-year disease-specific survival (DSS) as well as local control (LC) rates, with respect to T and N classification, status of surgical margins, and decision on neck management and adjuvant therapy. Cases were additionally evaluated for incidence of major complications and retention of laryngeal and pharyngeal function.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>DSS and LC rates of 72.6% and 85.4%, respectively, were noted overall in this series. Survival rates were found to be significantly better for cases with negative surgical margins. The presence of regional metastases was also found to significantly affect prognosis. Satisfactory retention of function and a low rate of major complications were noted.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>Laser surgery appears to be very effective for T1 and T2 hypopharyngeal cancer treatment as long as clear surgical margins can be achieved. Oncologic results are acceptable with low incidence of complications and satisfactory retention of function. The neck must always be included in the primary treatment plan of hypopharyngeal lesions. J. Surg. Oncol. J. Surg. Oncol. 2010;102:27–33. © 2010 Wiley-Liss, Inc.</p>\n </section>\n </div>","PeriodicalId":17111,"journal":{"name":"Journal of Surgical Oncology","volume":"102 1","pages":"27-33"},"PeriodicalIF":1.9000,"publicationDate":"2010-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/jso.21550","citationCount":"44","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Surgical Oncology","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/jso.21550","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ONCOLOGY","Score":null,"Total":0}

引用次数: 44

Abstract

Background and Objective

To assess the oncologic results and functional outcomes of CO₂ laser microsurgery in T1 and T2 hypopharyngeal cancer.

Methods

The files of 119 T1 and T2 hypopharyngeal carcinoma cases primarily managed with laser surgery were reviewed. Cases were assessed for 5-year disease-specific survival (DSS) as well as local control (LC) rates, with respect to T and N classification, status of surgical margins, and decision on neck management and adjuvant therapy. Cases were additionally evaluated for incidence of major complications and retention of laryngeal and pharyngeal function.

Results

DSS and LC rates of 72.6% and 85.4%, respectively, were noted overall in this series. Survival rates were found to be significantly better for cases with negative surgical margins. The presence of regional metastases was also found to significantly affect prognosis. Satisfactory retention of function and a low rate of major complications were noted.

Conclusion

Laser surgery appears to be very effective for T1 and T2 hypopharyngeal cancer treatment as long as clear surgical margins can be achieved. Oncologic results are acceptable with low incidence of complications and satisfactory retention of function. The neck must always be included in the primary treatment plan of hypopharyngeal lesions. J. Surg. Oncol. J. Surg. Oncol. 2010;102:27–33. © 2010 Wiley-Liss, Inc.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

激光显微手术治疗T1和T2下咽癌†

背景与目的评价CO2激光显微手术治疗T1和T2下咽癌的肿瘤学结果和功能预后。方法回顾性分析119例以激光手术为主的T1、T2型下咽癌的临床资料。评估病例的5年疾病特异性生存率(DSS)和局部控制率(LC)，包括T和N分类、手术切缘状况、颈部管理和辅助治疗的决定。此外，还评估了主要并发症的发生率和喉咽功能的保留情况。结果DSS和LC率分别为72.6%和85.4%。发现手术切缘阴性的病例生存率明显更好。区域转移的存在也会显著影响预后。术后功能保持良好，主要并发症发生率低。结论只要手术切缘清晰，激光手术治疗T1和T2下咽癌是非常有效的。肿瘤结果可接受，并发症发生率低，功能保留令人满意。颈部必须始终包括在下咽病变的主要治疗计划。J.外科医生。中华外科杂志，2010;42(2):27 - 33。©2010 Wiley-Liss, Inc

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Journal of Surgical Oncology 医学-外科

CiteScore

4.70

自引率

4.00%

发文量

367

审稿时长

2 months

期刊介绍： The Journal of Surgical Oncology offers peer-reviewed, original papers in the field of surgical oncology and broadly related surgical sciences, including reports on experimental and laboratory studies. As an international journal, the editors encourage participation from leading surgeons around the world. The JSO is the representative journal for the World Federation of Surgical Oncology Societies. Publishing 16 issues in 2 volumes each year, the journal accepts Research Articles, in-depth Reviews of timely interest, Letters to the Editor, and invited Editorials. Guest Editors from the JSO Editorial Board oversee multiple special Seminars issues each year. These Seminars include multifaceted Reviews on a particular topic or current issue in surgical oncology, which are invited from experts in the field.