The C19-diterpenoid alkaloids.

Q1 Biochemistry, Genetics and Molecular Biology Alkaloids: Chemistry and Biology Pub Date : 2010-01-01 DOI:10.1016/s1099-4831(10)69001-3

Feng-Peng Wang, Qiao-Hong Chen

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引用次数: 53

Abstract

The diterpenoid alkaloids, with an intriguing chemistry and numerous varied bioactivities, constitute the largest and most complicated group of terpenoid alkaloids. Among them, the C19-diterpenoid alkaloids have attracted extensive and lasting attention from researchers. This chapter with 1075 references systematically summarizes the past 30 years of studies on the C19-diterpenoid alkaloids, covering the classification and distribution, biogenesis and biosynthesis, applications in the phytochemotaxonomy of Chinese Aconitum L., spectral properties (1H and 13C NMR, MS), X-ray crystallographic analysis, chemical reactions and chemical conversions (as a continuation of Volume 42 of this treatise), and pharmacological activity of this important group of alkaloids. This review on the C19-diterpenoid alkaloids, in combination with two previous reviews in this treatise (C20-diterpenoid alkaloids, Volume 59, and C18-diterpenoid alkaloids, Volume 67), will present readers with a complete and updated profile of the diterpenoid alkaloids. The only exception is the description of the total syntheses of the diterpenoid alkaloids, which will be summarized in a subsequent individual chapter.

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c19 -二萜生物碱。

二萜类生物碱具有奇特的化学性质和多种多样的生物活性，是萜类生物碱中最大、最复杂的一类。其中，c19 -二萜类生物碱引起了研究人员广泛而持久的关注。本章共1075篇参考文献，系统总结了近30年来c19 -二萜类生物碱的研究，包括分类与分布、生物发生与生物合成、在乌头植物化学分类中的应用、光谱性质(1H和13C NMR、MS)、x射线晶体分析、化学反应和化学转化(作为本论文第42卷的延续)以及这一重要生物碱类生物碱的药理活性。这篇关于c19 -二萜生物碱的综述，结合本论文之前的两篇综述(c20 -二萜生物碱，第59卷和c18 -二萜生物碱，第67卷)，将为读者提供一个完整和最新的二萜生物碱概况。唯一的例外是对二萜生物碱的全合成的描述，这将在随后的单独章节中进行总结。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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