[Association of the ABCG1 gene polymorphism with the susceptibility and severity of coronary atherosclerotic disease].

Q4 Medicine 中华医学遗传学杂志 Pub Date : 2010-10-01 DOI:10.3760/cma.j.issn.1003-9406.2010.05.007

Long Ma, Guang-hui Cheng, Hui Wang, Li Li, Yao-qin Gong, Qi-ji Liu

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引用次数: 2

Abstract

Objective: To investigate the association of the ATP-binding cassette sub-family G member 1 (ABCG1) gene polymorphisms with coronary atherosclerotic disease (CAD) in Chinese Han population.

Methods: A population based case-control association study was carried out in 541 patients with CAD and 649 healthy controls from Chinese Han population. Two single nucleotide polymorphisms (SNPs) of the ABCG1 gene were genotyped using polymerase chain reaction-restriction fragment length polymorphism. Logistic regression was used to compare the genotypic and allelic frequency difference.

Results: The frequency of allele C of rs225374 was significantly higher in the CAD patients than that in the healthy controls (OR=1.186, 95%CI: 1.009-1.394, P=0.039), while the difference was also significant in the male subgroup (OR=1.236, 95%CI: 1.014-1.506, P=0.036). A statistically higher frequency of rs1044317 allele A was found in the CAD patients in comparison to the healthy controls (OR=1.187, 95%CI: 1.009-1.397, P=0.039). In case-only association study, rs225374 showed significant association in the high Gensini score group compared with the low Gensini score group (OR=1.303, 95%CI: 1.024-1.657, P=0.031).

Conclusion: The two SNPs of the ABCG1 gene might be associated with the susceptibility and severity of CAD in Chinese Han population.

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[ABCG1基因多态性与冠状动脉粥样硬化疾病易感性和严重程度的关系]。

目的:探讨atp结合盒亚家族G成员1 (ABCG1)基因多态性与中国汉族冠状动脉粥样硬化疾病(CAD)的关系。方法:对中国汉族541例冠心病患者和649例健康对照者进行基于人群的病例-对照关联研究。采用聚合酶链反应-限制性片段长度多态性对ABCG1基因的两个单核苷酸多态性(snp)进行基因分型。采用Logistic回归比较基因型和等位基因频率差异。结果:冠心病患者rs225374等位基因C的频率显著高于健康对照组(OR=1.186, 95%CI: 1.009 ~ 1.394, P=0.039)，男性亚组差异也显著(OR=1.236, 95%CI: 1.014 ~ 1.506, P=0.036)。冠心病患者rs1044317等位基因A的频率高于健康对照组(OR=1.187, 95%CI: 1.009-1.397, P=0.039)。在单病例关联研究中，与Gensini评分低组相比，Gensini评分高组rs225374显示有显著相关性(OR=1.303, 95%CI: 1.024 ~ 1.657, P=0.031)。结论:ABCG1基因的两个snp位点可能与中国汉族人群冠心病的易感性和严重程度有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

中华医学遗传学杂志 Medicine-Medicine (all)

CiteScore

0.50

自引率

0.00%

发文量

9521

期刊介绍： Chinese Journal of Medical Genetics is a medical journal, founded in 1984, under the supervision of the China Association for Science and Technology, sponsored by the Chinese Medical Association (hosted by Sichuan University), and is now a monthly magazine, which attaches importance to academic orientation, adheres to the scientific, scholarly, advanced, and innovative, and has a certain degree of influence in the industry. Chinese Journal of Medical Genetics is a journal of Peking University, and is now included in Peking University Journal (Chinese Journal of Humanities and Social Sciences), CSCD Source Journals of Chinese Science Citation Database (with extended version), Statistical Source Journals (China Science and Technology Dissertation Outstanding Journals), Zhi.com (in Chinese), Wipu (in Chinese), Wanfang (in Chinese), CA Chemical Abstracts (U.S.), JST (Japan Science and Technology Science and Technology), and JST (Japan Science and Technology Science and Technology Research Center). ), JST (Japan Science and Technology Agency), Pж (AJ) Abstracts Journal (Russia), Copernicus Index (Poland), Cambridge Scientific Abstracts, Abstracts and Citation Database, Abstracts Magazine, Medical Abstracts, and so on.