The liver-specific microRNA miR-122: biology and therapeutic potential.

Witold Filipowicz, Helge Grosshans
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Abstract

MicroRNAs (miRNAs) are small noncoding RNAs that regulate the expression of a large fraction of genes in animals, plants, and protozoa. miRNA-mediated gene repression occurs posttranscriptionally, generally by base-pairing to the 3'-untranslated regions of target mRNAs, which inhibits protein synthesis and destabilizes the mRNA. In this chapter, we discuss the biological functions of miR-122, a highly abundant, liver-specific miRNA. We will review how studies of miR-122 helped to establish important new paradigms of miRNA-mediated regulation, as well as identifying miR-122 as a factor implicated in important human diseases, including cancer and hepatitis C. We discuss antisense strategies targeting miR-122 as a potential therapeutic approach to treat hepatitis C and possibly other diseases.

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肝脏特异性microRNA miR-122:生物学和治疗潜力。
MicroRNAs (miRNAs)是一种小的非编码rna,可调节动物、植物和原生动物中大部分基因的表达。mirna介导的基因抑制发生在转录后,通常通过与目标mRNA的3'-非翻译区域进行碱基配对,从而抑制蛋白质合成并使mRNA不稳定。在本章中,我们讨论了miR-122的生物学功能,miR-122是一种高度丰富的肝脏特异性miRNA。我们将回顾miR-122的研究如何帮助建立mirna介导调控的重要新范式,以及确定miR-122是涉及重要人类疾病(包括癌症和丙型肝炎)的一个因素。我们将讨论针对miR-122的反义策略,作为治疗丙型肝炎和其他疾病的潜在治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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