Translocation (3;8)(q27;q24) in two cases of triple hit lymphoma

Cancer Genetics and Cytogenetics Pub Date : 2010-12-01 DOI:10.1016/j.cancergencyto.2010.08.018

Cristina Motlló , Javier Grau , Jordi Juncà , Neus Ruiz , José-Luis Mate , Elisa Orna , José-Tomás Navarro , Susana Vives , Juan-Manuel Sancho , Daniel Esteban , Isabel Granada , Evarist Feliu , Josep-Maria Ribera , Fuensanta Millá

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引用次数: 21

Abstract

Unclassifiable lymphoma with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma is a new category of B-cell lymphoma appearing in the new World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues. This lymphoma usually shows MYC rearrangements with non-IGH genes in the setting of a complex karyotype possibly involving BCL2 and, less frequently, BCL6 rearrangements. According to the presence of two or three rearrangements, these lymphomas are called double-hit lymphomas or triple-hit lymphomas (THL), respectively. Here we report two cases of THL with MYC, BCL2, and BCL6 rearrangements and t(3;8)(q27;q24) diagnosed in one center in the last two years.

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2例三发淋巴瘤的易位(3;8)(q27;q24)

不可分性淋巴瘤是世界卫生组织新的《造血和淋巴组织肿瘤分类》中出现的一种新的b细胞淋巴瘤，其特征介于弥漫性大b细胞淋巴瘤和伯基特淋巴瘤之间。这种淋巴瘤通常表现为MYC重排与非igh基因在复杂核型的背景下，可能涉及BCL2和较少的BCL6重排。根据存在两种或三种重排，这些淋巴瘤分别被称为双击淋巴瘤或三击淋巴瘤(THL)。在这里，我们报告两例THL伴MYC、BCL2和BCL6重排和t(3;8)(q27;q24)在过去两年中在一个中心诊断。

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Cancer Genetics and Cytogenetics 医学-遗传学

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