Therapeutic vaccination in chronic hepatitis B: preclinical studies in the woodchuck.

Hepatitis research and treatment Pub Date : 2010-01-01 Epub Date: 2010-09-07 DOI:10.1155/2010/817580
Anna D Kosinska, Ejuan Zhang, Mengji Lu, Michael Roggendorf
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引用次数: 25

Abstract

Recommended treatment of chronic hepatitis B with interferon-α and/or nucleos(t)ide analogues does not lead to a satisfactory result. Induction of HBV-specific T cells by therapeutic vaccination or immunotherapies may be an innovative strategy to overcome virus persistence. Vaccination with commercially available HBV vaccines in patients did not result in effective control of HBV infection, suggesting that new formulations of therapeutic vaccines are needed. The woodchuck (Marmota monax) is a useful preclinical model for developing the new therapeutic approaches in chronic hepadnaviral infections. Several innovative approaches combining antiviral treatments with nucleos(t)ide analogues, DNA vaccines, and protein vaccines were tested in the woodchuck model. In this paper we summarize the available data concerning therapeutic immunization and gene therapy using recombinant viral vectors approaches in woodchucks, which show encouraging results. In addition, we present potential innovations in immunomodulatory strategies to be evaluated in this animal model.

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慢性乙型肝炎的治疗性疫苗接种:土拨鼠的临床前研究。
推荐使用干扰素-α和/或核苷(t)类似物治疗慢性乙型肝炎,结果并不令人满意。通过治疗性疫苗接种或免疫疗法诱导HBV特异性T细胞可能是克服病毒持久性的创新策略。在患者中接种市售HBV疫苗并不能有效控制HBV感染,这表明需要新的治疗性疫苗配方。土拨鼠(Marmota monax)是一种有用的临床前模型,可用于开发慢性肝炎病毒感染的新治疗方法。在土拨鼠模型中测试了几种将抗病毒治疗与核苷类似物、DNA疫苗和蛋白质疫苗相结合的创新方法。在这篇论文中,我们总结了关于在木拨鼠中使用重组病毒载体方法进行治疗性免疫和基因治疗的现有数据,这些数据显示出令人鼓舞的结果。此外,我们提出了免疫调节策略的潜在创新,将在该动物模型中进行评估。
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