Investigation of oxidative stress in pterygium tissue.

IF 1.4 3区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Molecular Vision Pub Date : 2011-02-09

Mehmet Balci, Semsettin Sahin, Fatih Mehmet Mutlu, Ramazan Yağci, Pınar Karanci, Metin Yildiz

{"title":"Investigation of oxidative stress in pterygium tissue.","authors":"Mehmet Balci, Semsettin Sahin, Fatih Mehmet Mutlu, Ramazan Yağci, Pınar Karanci, Metin Yildiz","doi":"","DOIUrl":null,"url":null,"abstract":"Purpose: To investigate changes in the oxidant-antioxidant system in pterygium tissue.Methods: Tissue samples ablated from 40 patients during pterygium surgery constituted the study material, while normal nasal conjunctiva tissue samples from 20 patients matched for age group (who had undergone surgery for strabismus or extracapsular cataract surgery) were used as controls. The samples were kept at -70 °C until the time of analysis. Catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) enzymatic activity and the levels of nitric oxide (NO) and malone dialdehyde (MDA) were studied in both groups.Results: The mean age was 54.0±12 years in the pterygium patients and 49.0±19 in the controls (p=0.270). The enzyme activity levels were significantly lower in the pterygium group when compared to the controls (p<0.001 in each case), while in the same group a significant increase was observed in the MDA and NO levels (also p<0.001, in both cases).Conclusions: These findings indicating oxidative stress in the pterygium tissue suggest that oxidative stress can play a role in pterygium etiopathogenesis.","PeriodicalId":18866,"journal":{"name":"Molecular Vision","volume":" ","pages":"443-7"},"PeriodicalIF":1.4000,"publicationDate":"2011-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038211/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecular Vision","FirstCategoryId":"3","ListUrlMain":"","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose: To investigate changes in the oxidant-antioxidant system in pterygium tissue.

Methods: Tissue samples ablated from 40 patients during pterygium surgery constituted the study material, while normal nasal conjunctiva tissue samples from 20 patients matched for age group (who had undergone surgery for strabismus or extracapsular cataract surgery) were used as controls. The samples were kept at -70 °C until the time of analysis. Catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) enzymatic activity and the levels of nitric oxide (NO) and malone dialdehyde (MDA) were studied in both groups.

Results: The mean age was 54.0±12 years in the pterygium patients and 49.0±19 in the controls (p=0.270). The enzyme activity levels were significantly lower in the pterygium group when compared to the controls (p<0.001 in each case), while in the same group a significant increase was observed in the MDA and NO levels (also p<0.001, in both cases).

Conclusions: These findings indicating oxidative stress in the pterygium tissue suggest that oxidative stress can play a role in pterygium etiopathogenesis.

微信好友朋友圈 QQ好友复制链接

本刊更多论文

翼状胬肉组织氧化应激的研究。

目的:探讨翼状胬肉组织氧化-抗氧化系统的变化。方法:选取40例翼状胬肉手术患者的消融组织样本作为研究材料，选取20例符合年龄组(斜视或白内障囊外手术)的正常鼻结膜组织样本作为对照。样品保存在-70°C直到分析时间。观察两组小鼠过氧化氢酶(CAT)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)活性及一氧化氮(NO)、丙二醛(MDA)水平。结果:翼状胬肉组平均年龄为54.0±12岁，对照组平均年龄为49.0±19岁(p=0.270)。与对照组相比，翼状胬肉组的酶活性水平显著降低(结论:这些发现表明翼状胬肉组织中的氧化应激提示氧化应激在翼状胬肉的发病过程中起作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Molecular Vision 生物-生化与分子生物学

CiteScore

4.40

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： Molecular Vision is a peer-reviewed journal dedicated to the dissemination of research results in molecular biology, cell biology, and the genetics of the visual system (ocular and cortical). Molecular Vision publishes articles presenting original research that has not previously been published and comprehensive articles reviewing the current status of a particular field or topic. Submissions to Molecular Vision are subjected to rigorous peer review. Molecular Vision does NOT publish preprints. For authors, Molecular Vision provides a rapid means of communicating important results. Access to Molecular Vision is free and unrestricted, allowing the widest possible audience for your article. Digital publishing allows you to use color images freely (and without fees). Additionally, you may publish animations, sounds, or other supplementary information that clarifies or supports your article. Each of the authors of an article may also list an electronic mail address (which will be updated upon request) to give interested readers easy access to authors.