Study on swelling, compression property and degradation stability of PVA composite hydrogels for artificial nucleus pulposus

IF 3.3 2区医学 Q2 ENGINEERING, BIOMEDICAL Journal of the Mechanical Behavior of Biomedical Materials Pub Date : 2022-12-01 DOI:10.1016/j.jmbbm.2022.105496

Dingding Xiang , Yangyang Cui , Zhiping Wan , Song Wang , Lu Peng , Zhenhua Liao , Changsheng Chen , Weiqiang Liu

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引用次数: 5

Abstract

Artificial nucleus pulposus (ANP) replacement as an alternative to the treatment of cervical spondylosis aims to relieve pain and restore the normal cervical motion. In this study, the PVA/PVP and PVA/Pectin composite hydrogels (CH)s with different concentrations were prepared by the freezing–thawing process, and their performances were tested. The effect of different concentrations on both kinds of PVA CHs were evaluated and analysed. The results demonstrated that both kinds of CHs had good swelling property (¿190%), compressive stress–strain characteristic response and stable performance, and they were not easy to degrade (¡9%). The elastic modulus of the PVA/PVP CH was close to that of nucleus pulposus prosthesis, and the weight loss ratio of the PVA/PVP CH was lower than that of PVA/Pectin CH under load condition. Further, the experimental results showed that the PVA/PVP CH with 15 wt% solute and 1 wt% PVP content had the best comprehensive performance, which may provide significant advantages for use in future clinical application in replacing nucleus pulposus.

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人造髓核用聚乙烯醇复合水凝胶的膨胀、压缩性能及降解稳定性研究

人工髓核(ANP)置换术作为治疗颈椎病的一种替代方法，其目的是缓解疼痛，恢复颈椎的正常运动。本研究采用冻融法制备了不同浓度的PVA/PVP和PVA/Pectin复合水凝胶(CH)s，并对其性能进行了测试。评价和分析了不同浓度对两种PVA - CHs的影响。结果表明，两种CHs均具有良好的溶胀性能(¿190%)、压应力-应变特性响应和稳定的性能，且不易降解(±9%)。PVA/PVP CH的弹性模量接近髓核假体的弹性模量，载荷条件下PVA/PVP CH的失重率低于PVA/果胶CH。此外，实验结果表明，溶质含量为15 wt%、PVP含量为1 wt%的PVA/PVP CH综合性能最佳，为将来临床应用于髓核替代提供了显著优势。

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来源期刊

Journal of the Mechanical Behavior of Biomedical Materials 工程技术-材料科学：生物材料

CiteScore

7.20

自引率

7.70%

发文量

505

审稿时长

46 days

期刊介绍： The Journal of the Mechanical Behavior of Biomedical Materials is concerned with the mechanical deformation, damage and failure under applied forces, of biological material (at the tissue, cellular and molecular levels) and of biomaterials, i.e. those materials which are designed to mimic or replace biological materials. The primary focus of the journal is the synthesis of materials science, biology, and medical and dental science. Reports of fundamental scientific investigations are welcome, as are articles concerned with the practical application of materials in medical devices. Both experimental and theoretical work is of interest; theoretical papers will normally include comparison of predictions with experimental data, though we recognize that this may not always be appropriate. The journal also publishes technical notes concerned with emerging experimental or theoretical techniques, letters to the editor and, by invitation, review articles and papers describing existing techniques for the benefit of an interdisciplinary readership.