Elevated concentrations of matrix metalloproteinase-12 and elastin degradation products in the sera of pregnant women infected with Toxoplasma gondii.

Abstract

Although the expression of matrix metalloproteinase-12 (MMP-12) appears to be increased in most inflammatory diseases, the role of this enzyme in the pathogenesis of toxoplasmosis in pregnant women, if any, is unknown. In a recent study in Taiwan, the serum concentrations of MMP-12 and its substrate elastin were evaluated in pregnant women with Toxoplasma gondii infection. Compared with the healthy pregnant and non-pregnant women used as controls, the pregnant women with toxoplasmosis had significantly higher serum concentrations of MMP-12 and significantly higher levels of elastin synthesis and degradation. Interaction between MMP-12 and elastin in the serum samples was confirmed by co-immunoprecipitation. It seems possible that MMP-12 may contribute to elastin degradation occurring during the pathogenesis of toxoplasmosis in pregnant women.