Attitudes toward vaccination for pandemic H1N1 and seasonal influenza in patients with hematologic malignancies.

Abstract

Background: Patients with hematologic malignancies are at increased risk of influenza and its complications. Despite current health recommendations and evidence favoring influenza vaccination, vaccination rates remain low in cancer patients.

Objective: The purpose of this study was to determine which factors influenced vaccination rates.

Methods: During the 2009-2010 pandemic H1N1 and seasonal influenza season, we surveyed patients with hematologic malignancies in a Canadian cancer center. Of the patients participating in our study (n = 129), 66% and 57% received the H1N1 pandemic influenza and seasonal influenza vaccines, respectively.

Results: A number of reasons for vaccination refusal were reported, most relating to general skepticism about the safety and efficacy of vaccination. Physician advice was also a factor influencing vaccination rates in patients. The vaccination rate for seasonal influenza was 39% in patients < 65 years old, significantly lower than the rate of 73% reported for patients aged > or = 65 years (P < 0.0001).

Conclusion: Future education programs should target younger patient populations and health-care workers, focusing on vaccine safety and efficacy in the high-risk cancer population.