[Successful treatment of invasive pulmonary aspergillosis with a fungus ball and infiltration by the long-term administration of liposomal amphotericin B].

Abstract

A 64-year-old diabetic man was admitted because his general condition had not improved despite the admini stration of voriconazole in another hospital, and his condition had become critical. Chest CT demonstrated a large fungus ball and consolidation around a cavity in the right lung. Aspergillusfumigatus was detected on a sputum culture. Based on these findings, we diagnosed invasive aspergillosis and administered high-dose (5mg/kg) liposomal amphotericin B (L-AMB) for 8 weeks, which resulted in the improvement of his general condition and the disappearance of the fungus ball, without severe adverse events.