Ethnicity-specific anthropometric predictors of metabolic risk in women.

Nikki C Bush, Jessica A Alvarez, Gary R Hunter, David W Brock, Paula C Chandler-Laney, Barbara A Gower
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Abstract

OBJECTIVE: The objective of this study was to determine associations of anthropometric measures of thigh and abdominal adipose tissue with metabolic risk factors, and whether these associations differed with ethnicity. We hypothesized that thigh circumference (ThC) would have an independent favorable association with insulin sensitivity, lipids, and blood pressure, whereas waist circumference (WC) would have an independent deleterious association with these variables in both African Americans (AA) and European Americans (EA). METHODS: Subjects were 228 healthy, overweight, premenopausal AA and EA women. Insulin sensitivity was assessed by intravenous glucose tolerance test and minimal modeling. Simple relationships between anthropometric measures and risk factors were determined by Pearson correlation analysis. Partial correlation coefficients were determined for circumference measures adjusted for thigh and abdominal skinfolds to differentiate relationships between thigh and abdominal subcutaneous fat from thigh muscle and deeper abdominal fat, respectively. RESULTS: In EA but not AA, ThC was positively associated with insulin sensitivity, independent of thigh skinfold. In both EA and AA, ThC was associated with a desirable lipid profile. In AA but not EA, WC was associated with lower insulin sensitivity and a less desirable metabolic profile. CONCLUSION: Results suggest that thigh muscle (ThC adjusted for thigh skinfold) may be metabolically protective in EA but not AA. In contrast, WC was a better indicator of insulin sensitivity and metabolic health in AA. Further investigation is needed to verify the association between thigh muscle and metabolic health, and to probe the reason for the observed ethnic specificity of the associations between anthropometric measures and metabolic risk factors.

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女性代谢风险的种族特异性人体测量预测因子。
目的:本研究的目的是确定大腿和腹部脂肪组织的人体测量测量与代谢危险因素的关联,以及这些关联是否因种族而异。我们假设大腿围(ThC)与胰岛素敏感性、血脂和血压有独立的有利关联,而腰围(WC)与这些变量在非洲裔美国人(AA)和欧洲裔美国人(EA)中都有独立的有害关联。方法:228名健康、超重、绝经前AA和EA妇女。通过静脉葡萄糖耐量试验和最小模型评估胰岛素敏感性。通过Pearson相关分析确定人体测量值与危险因素之间的简单关系。对大腿和腹部皮肤褶皱进行校正后的围度测量确定了偏相关系数,以区分大腿和腹部皮下脂肪与大腿肌肉和腹部深层脂肪之间的关系。结果:EA患者ThC与胰岛素敏感性呈正相关,与大腿皮褶无关。在EA和AA中,ThC与理想的脂质谱有关。在AA而非EA中,WC与较低的胰岛素敏感性和较不理想的代谢谱相关。结论:结果表明大腿肌肉(大腿皮褶调整的ThC)可能对EA有代谢保护作用,但对AA没有。相比之下,WC是AA患者胰岛素敏感性和代谢健康的较好指标。需要进一步的研究来验证大腿肌肉与代谢健康之间的关联,并探讨人体测量测量与代谢危险因素之间的关联存在民族特异性的原因。
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