Activity of Cathelicidin Peptides against Simkania negevensis.

International Journal of Peptides Pub Date : 2011-01-01 Epub Date: 2011-04-05 DOI:10.1155/2011/708710
Manuela Donati, Antonietta Di Francesco, Maria Di Paolo, Natascia Fiani, Monica Benincasa, Renato Gennaro, Paola Nardini, Claudio Foschi, Roberto Cevenini
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引用次数: 1

Abstract

The in vitro activity of six cathelicidin peptides against the reference strain Z of Simkania negevensis was investigated. Five peptides-PG-1, Bac7, SMAP-29, BMAP-27, and BMAP-28-proved to be active at very low concentrations (1 to 0.1 μg/mL), while LL-37 cathelicidin was ineffective even at a concentration of 100 μg/mL. In comparison to chlamydiae, S. negevensis proved to be more susceptible to the antimicrobial peptides tested.

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抗菌肽对阴性狐蚜的活性研究。
研究了6种抗菌肽对阴性Simkania negevensis参比菌株Z的体外活性。5个肽- pg -1、Bac7、SMAP-29、BMAP-27和bmap -28在极低浓度(1 ~ 0.1 μg/mL)下具有活性,而LL-37在100 μg/mL浓度下也无效。与衣原体相比,阴性葡萄球菌对抗菌肽更敏感。
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