Manuela Donati, Antonietta Di Francesco, Maria Di Paolo, Natascia Fiani, Monica Benincasa, Renato Gennaro, Paola Nardini, Claudio Foschi, Roberto Cevenini
{"title":"Activity of Cathelicidin Peptides against Simkania negevensis.","authors":"Manuela Donati, Antonietta Di Francesco, Maria Di Paolo, Natascia Fiani, Monica Benincasa, Renato Gennaro, Paola Nardini, Claudio Foschi, Roberto Cevenini","doi":"10.1155/2011/708710","DOIUrl":null,"url":null,"abstract":"<p><p>The in vitro activity of six cathelicidin peptides against the reference strain Z of Simkania negevensis was investigated. Five peptides-PG-1, Bac7, SMAP-29, BMAP-27, and BMAP-28-proved to be active at very low concentrations (1 to 0.1 μg/mL), while LL-37 cathelicidin was ineffective even at a concentration of 100 μg/mL. In comparison to chlamydiae, S. negevensis proved to be more susceptible to the antimicrobial peptides tested.</p>","PeriodicalId":14239,"journal":{"name":"International Journal of Peptides","volume":"2011 ","pages":"708710"},"PeriodicalIF":0.0000,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2011/708710","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Peptides","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1155/2011/708710","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2011/4/5 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
Abstract
The in vitro activity of six cathelicidin peptides against the reference strain Z of Simkania negevensis was investigated. Five peptides-PG-1, Bac7, SMAP-29, BMAP-27, and BMAP-28-proved to be active at very low concentrations (1 to 0.1 μg/mL), while LL-37 cathelicidin was ineffective even at a concentration of 100 μg/mL. In comparison to chlamydiae, S. negevensis proved to be more susceptible to the antimicrobial peptides tested.