The genetic basis of craniofacial and dental abnormalities.

Schweizer Monatsschrift fur Zahnmedizin = Revue mensuelle suisse d'odonto-stomatologie = Rivista mensile svizzera di odontologia e stomatologia Pub Date : 2011-01-01

Thaleia Kouskoura, Natassa Fragou, Maria Alexiou, Nessy John, Lukas Sommer, Daniel Graf, Christos Katsaros, Thimios A Mitsiadis

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Abstract

The embryonic head development, including the formation of dental structures, is a complex and delicate process guided by specific genetic programs. Genetic changes and environmental factors can disturb the execution of these programs and result in abnormalities in orofacial and dental structures. Orofacial clefts and hypodontia/ oligodontia are examples of such abnormalities frequently seen in dental clinics. An insight into the mechanisms and genes involved in the formation of orofacial and dental structures has been gradually gained by genetic analysis of families and by the use of experimental vertebrate models such as the mouse and chick models. The development of novel clinical therapies for orofacial and dental pathological conditions depends very much on a detailed knowledge of the molecular and cellular processes that are involved in head formation.

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颅面和牙齿畸形的遗传基础。

胚胎头的发育，包括牙齿结构的形成，是一个复杂而微妙的过程，由特定的遗传程序指导。遗传变化和环境因素会干扰这些程序的执行，并导致口腔和牙齿结构的异常。口腔面部裂和牙下/少齿症是这种异常的例子，经常在牙科诊所看到。通过对家族的遗传分析和使用实验脊椎动物模型，如小鼠和小鸡模型，人们逐渐了解了参与口腔面部和牙齿结构形成的机制和基因。新型临床治疗口腔面部和牙齿病理条件的发展在很大程度上依赖于参与头部形成的分子和细胞过程的详细知识。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Schweizer Monatsschrift fur Zahnmedizin = Revue mensuelle suisse d'odonto-stomatologie = Rivista mensile svizzera di odontologia e stomatologia

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