Caudate nucleus and insular activation during a pain suppression paradigm comparing thermal and electrical stimulation.

Q4 Medicine Open Neuroimaging Journal Pub Date : 2011-01-01 Epub Date: 2011-01-18 DOI:10.2174/1874440001105010001
Arthur P Wunderlich, Roland Klug, Gregor Stuber, Bernhard Landwehrmeyer, Frank Weber, Wolfgang Freund
{"title":"Caudate nucleus and insular activation during a pain suppression paradigm comparing thermal and electrical stimulation.","authors":"Arthur P Wunderlich,&nbsp;Roland Klug,&nbsp;Gregor Stuber,&nbsp;Bernhard Landwehrmeyer,&nbsp;Frank Weber,&nbsp;Wolfgang Freund","doi":"10.2174/1874440001105010001","DOIUrl":null,"url":null,"abstract":"<p><p>Pain modulation is an integral function of the nervous system. It is needed to adapt to chronic stimuli. To gain insights into pain suppression mechanisms, two studies concerning the suppression of the feeling of pain with different stimulation modalities (heat vs. electrical stimuli) but using the same stimulation paradigms were compared: 15 subjects each had been stimulated on both hands under the instruction to suppress the feeling of pain. Anterior insula and DLPFC activation was seen in both single modality studies and seems to be a common feature of pain suppression, as it is absent in the interaction analyses presented here. During the task to suppress the feeling of pain, there were no consistent activations stronger under thermostimulation. But during electrostimulation, there was significantly stronger activation than during thermal stimulation in the caudate nucleus bilaterally and in the contralateral posterior insula. This may be attributed to the higher sensory-discriminative content and more demand on subjective rating and suppression of the painful electrical stimulus, compared to thermostimulation. The caudate nucleus seems to play an important role not only in the motor system but also in the modulation of the pain experience.</p>","PeriodicalId":37431,"journal":{"name":"Open Neuroimaging Journal","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/92/e2/TONIJ-5-1.PMC3106353.pdf","citationCount":"40","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Open Neuroimaging Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1874440001105010001","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2011/1/18 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 40

Abstract

Pain modulation is an integral function of the nervous system. It is needed to adapt to chronic stimuli. To gain insights into pain suppression mechanisms, two studies concerning the suppression of the feeling of pain with different stimulation modalities (heat vs. electrical stimuli) but using the same stimulation paradigms were compared: 15 subjects each had been stimulated on both hands under the instruction to suppress the feeling of pain. Anterior insula and DLPFC activation was seen in both single modality studies and seems to be a common feature of pain suppression, as it is absent in the interaction analyses presented here. During the task to suppress the feeling of pain, there were no consistent activations stronger under thermostimulation. But during electrostimulation, there was significantly stronger activation than during thermal stimulation in the caudate nucleus bilaterally and in the contralateral posterior insula. This may be attributed to the higher sensory-discriminative content and more demand on subjective rating and suppression of the painful electrical stimulus, compared to thermostimulation. The caudate nucleus seems to play an important role not only in the motor system but also in the modulation of the pain experience.

Abstract Image

Abstract Image

Abstract Image

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
在疼痛抑制模式下的尾状核和岛岛的激活比较热刺激和电刺激。
疼痛调节是神经系统不可或缺的功能。它需要适应慢性刺激。为了深入了解疼痛抑制机制,我们比较了两项使用相同刺激范式的不同刺激方式(热刺激和电刺激)抑制疼痛感觉的研究:15名受试者在抑制疼痛感觉的指导下,分别对双手进行刺激。在两项单模态研究中都发现了前脑岛和DLPFC的激活,这似乎是疼痛抑制的共同特征,因为在本文的相互作用分析中没有发现。在抑制疼痛感的任务中,在热刺激下没有一致的更强的激活。但在电刺激时,双侧尾状核和对侧后岛的激活明显强于热刺激。这可能是由于与热刺激相比,痛觉电刺激具有更高的感觉鉴别内容,更需要主观评价和抑制。尾状核似乎不仅在运动系统中起重要作用,而且在疼痛体验的调节中也起重要作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Open Neuroimaging Journal
Open Neuroimaging Journal Medicine-Radiology, Nuclear Medicine and Imaging
CiteScore
0.70
自引率
0.00%
发文量
3
期刊介绍: The Open Neuroimaging Journal is an Open Access online journal, which publishes research articles, reviews/mini-reviews, and letters in all important areas of brain function, structure and organization including neuroimaging, neuroradiology, analysis methods, functional MRI acquisition and physics, brain mapping, macroscopic level of brain organization, computational modeling and analysis, structure-function and brain-behavior relationships, anatomy and physiology, psychiatric diseases and disorders of the nervous system, use of imaging to the understanding of brain pathology and brain abnormalities, cognition and aging, social neuroscience, sensorimotor processing, communication and learning.
期刊最新文献
Correlation of MRI Findings with ODI and VAS Score in Patients with Lower Back Pain Divergences Between Resting State Networks and Meta-Analytic Maps Of Task-Evoked Brain Activity Trends in DNN Model Based Classification and Segmentation of Brain Tumor Detection Analysis of Brain Structure and Neural Organization in Dystrophin-Deficient Model Mice with Magnetic Resonance Imaging at 7 T Unusual Intracranial Manifestation of Infective Endocarditis
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1