Dynamic aerobic exercise induces baroreflex improvement in diabetic rats.

Experimental Diabetes Research Pub Date : 2012-01-01 Epub Date: 2011-12-10 DOI:10.1155/2012/108680

Luciana Jorge, Demilto Y da Pureza, Danielle da Silva Dias, Filipe Fernandes Conti, Maria-Cláudia Irigoyen, Kátia De Angelis

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引用次数: 11

Abstract

The objective of the present study was to investigate the effects of an acute aerobic exercise on arterial pressure (AP), heart rate (HR), and baroreflex sensitivity (BRS) in STZ-induced diabetic rats. Male Wistar rats were divided into control (n = 8) and diabetic (n = 8) groups. AP, HR, and BRS, which were measured by tachycardic and bradycardic (BR) responses to AP changes, were evaluated at rest (R) and postexercise session (PE) on a treadmill. At rest, STZ diabetes induced AP and HR reductions, associated with BR impairment. Attenuation in resting diabetes-induced AP (R: 103 ± 2 versus PE: 111 ± 3 mmHg) and HR (R: 290 ± 7 versus PE: 328 ± 10 bpm) reductions and BR dysfunction (R: -0.70 ± 0.06 versus PE: -1.21 ± 0.09 bpm/mmHg) was observed in the postexercise period. In conclusion, the hemodynamic and arterial baro-mediated control of circulation improvement in the postexercise period reinforces the role of exercise in the management of cardiovascular risk in diabetes.

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动态有氧运动可改善糖尿病大鼠的压力反射。

本研究旨在探讨急性有氧运动对stz诱导的糖尿病大鼠动脉压(AP)、心率(HR)和压力反射敏感性(BRS)的影响。雄性Wistar大鼠分为对照组(n = 8)和糖尿病组(n = 8)。AP、HR和BRS是通过对AP变化的心动过速和心动过缓(BR)反应来测量的，在休息(R)和运动后(PE)的跑步机上进行评估。静息时，STZ糖尿病诱导AP和HR降低，与BR损伤相关。运动后观察到静息糖尿病诱导的AP (R: 103±2 vs PE: 111±3 mmHg)和HR (R: 290±7 vs PE: 328±10 bpm)降低和BR功能障碍(R: -0.70±0.06 vs PE: -1.21±0.09 bpm/mmHg)的衰减。总之，运动后血液动力学和动脉气压介导的循环改善控制强化了运动在糖尿病心血管风险管理中的作用。

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Experimental Diabetes Research 医学-内分泌学与代谢

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3-8 weeks