Influence of obesity-susceptibility loci (MC4R and INSIG2) on the outcome of weight loss and amelioration of co-morbidity in obese patients treated by a gastric-bypass.

Bulletin de la Societe des sciences medicales du Grand-Duche de Luxembourg Pub Date : 2011-01-01

M Goergen, D Manzoni, V De Blasi, P Fabiano, V Poulain, L De Magistris, V Simonelli, K Dahan, J-S Azagra

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Abstract

Background: Genome-wide association and linkage studies have identified multiple susceptibility loci for obesity.

Objective: We hypothesized that such loci may affect weight loss and comorbidity amelioration outcomes following a gastric-bypass.

Design: A total of 200 obese patients who underwent a gastric bypass surgery were genotyped for single-nucleotide polymorphisms (SNPs) in insulin induced gene 2 (INSIG2) and melanocortin 4 receptor (MC4R) obesity genes.

Results: After a follow-up of 18 month, the patients (192) data of weight excess loss (72%) and co-morbidities (Hypertension -62- and Diabetes -39-) were analyzed and compared. 26 Patients with SNP were found (9 MC4R and 17 INSIG2). No significant differences in weight excess loss and amelioration of comorbidities were revealed.

Conclusions: The data suggest no influence of weight excess loss and amelioration of co-morbidities after gastric-bypass by genetic susceptibility.

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肥胖易感基因座(MC4R和INSIG2)对胃旁路治疗肥胖患者体重减轻和合并症改善的影响

背景:全基因组关联和连锁研究已经确定了肥胖的多个易感位点。目的:我们假设这些基因座可能影响胃旁路手术后的体重减轻和合并症改善结果。设计:共有200名接受胃旁路手术的肥胖患者进行了胰岛素诱导基因2 (INSIG2)和黑素皮质素4受体(MC4R)肥胖基因的单核苷酸多态性(snp)基因分型。结果:经过18个月的随访，对192例患者体重减轻(72%)和合并症(高血压-62-和糖尿病-39-)进行了分析和比较。发现SNP 26例(MC4R 9例，INSIG2 17例)。在体重减轻和合并症的改善方面没有显着差异。结论:这些数据表明遗传易感性对胃分流术后体重减轻和合并症的改善没有影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Bulletin de la Societe des sciences medicales du Grand-Duche de Luxembourg

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