Time-dependent alterations in rat macrovessels with type 1 diabetes.

Experimental Diabetes Research Pub Date : 2012-01-01 Epub Date: 2012-01-23 DOI:10.1155/2012/278620
Yvonne Searls, Irina V Smirnova, Lisa Vanhoose, Barbara Fegley, Rajprasad Loganathan, Lisa Stehno-Bittel
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引用次数: 20

Abstract

Vascular complications are associated with the progressive severity of diabetes, resulting in significant morbidity and mortality. This study quantifies functional vascular parameters and macrovascular structure in a rat model of type 1 diabetes. While there was no difference in the systemic arterial elastance (Ea) with 50 days of diabetes, changes were noted in the aorta and femoral artery including increased tunica media extracellular matrix content, decreased width of both the media and individual smooth muscle cell layers, and increased incidence of damaged mitochondria. Extracellular matrix proteins and elastin levels were significantly greater in the aorta of diabetic animals. These differences correlated with diminished matrix metalloprotease activity in the aorta of the diabetic animals. In conclusion, diabetes significantly altered the structure and ultrastructure of the aorta and femoral artery before systemic changes in arterial elastance could be detected.

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1型糖尿病大鼠大血管的时间依赖性改变。
血管并发症与糖尿病的进展严重程度相关,导致显著的发病率和死亡率。本研究量化了1型糖尿病大鼠模型的功能血管参数和大血管结构。虽然糖尿病患者50天的全身动脉弹性(Ea)没有差异,但主动脉和股动脉发生了变化,包括中膜细胞外基质含量增加,中膜和单个平滑肌细胞层宽度减小,线粒体损伤发生率增加。糖尿病动物主动脉细胞外基质蛋白和弹性蛋白水平明显升高。这些差异与糖尿病动物主动脉基质金属蛋白酶活性降低有关。综上所述,糖尿病显著改变了主动脉和股动脉的结构和超微结构,然后才检测到全身动脉弹性的变化。
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来源期刊
Experimental Diabetes Research
Experimental Diabetes Research 医学-内分泌学与代谢
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3-8 weeks
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