Microvascular autoregulation in children and adolescents with type 1 diabetes mellitus.

IF 10.2 1区医学 Q1 ENDOCRINOLOGY & METABOLISM Diabetologia Pub Date : 2012-06-01 Epub Date: 2012-02-26 DOI:10.1007/s00125-012-2502-8

O Schlager, A Hammer, A Willfort-Ehringer, M Fritsch, B Rami-Merhar, E Schober, K Nagl, A Giurgea, C Margeta, S Zehetmayer, G H Schernthaner, R Koppensteiner, M E Gschwandtner

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引用次数: 18

Abstract

Aims/hypothesis: Deterioration of microvascular function may have an early onset in individuals with type 1 diabetes mellitus. We hypothesised that microvascular autoregulation is impaired in children with type 1 diabetes and can be detected non-invasively by postocclusive reactive hyperaemia (PORH).

Methods: Microvascular autoregulation was assessed in 58 children with type 1 diabetes and 58 age- and sex-matched healthy controls by PORH using laser Doppler fluxmetry. Baseline perfusion, biological zero (defined as a 'no flow' laser Doppler signal during suprasystolic occlusion), peak perfusion following occlusion, time to peak and recovery time (time until baseline perfusion is resumed) were recorded and compared between the groups.

Results: Peak perfusion was higher in children with type 1 diabetes than in healthy controls (1.7 ± 0.93 AU [arbitrary units] vs 1.29 ± 0.46 AU; p = 0.004), and biological zero was lower in children with type 1 diabetes vs controls (0.14 ± 0.04 AU vs 0.19 ± 0.04 AU; p < 0.0001). No differences were seen between the groups in baseline perfusion, time to peak during PORH and recovery time following PORH.

Conclusions/interpretation: PORH reveals impaired microvascular autoregulation in children with type 1 diabetes. The higher peak perfusion might reflect a decline in the vasoconstrictive ability of arteriolar smooth muscle cells upstream of capillary beds in children with type 1 diabetes.

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儿童和青少年1型糖尿病的微血管自我调节。

目的/假设:1型糖尿病患者微血管功能恶化可能早发。我们假设1型糖尿病儿童的微血管自身调节功能受损，可以通过闭合性反应性充血(PORH)无创检测。方法:应用激光多普勒通量法对58例1型糖尿病儿童和58例年龄和性别匹配的健康对照者的微血管自动调节进行PORH评价。记录各组基线灌注、生物零(定义为收缩期上闭塞时“无血流”激光多普勒信号)、闭塞后灌注峰值、达到峰值的时间和恢复时间(恢复基线灌注的时间)并进行比较。结果:1型糖尿病儿童的灌注峰值高于健康对照组(1.7±0.93 AU[任意单位]vs 1.29±0.46 AU;p = 0.004)， 1型糖尿病儿童的生物学零值低于对照组(0.14±0.04 AU vs 0.19±0.04 AU;P < 0.0001)。各组间的基线灌注、PORH时的峰值时间和PORH后的恢复时间均无差异。结论/解释:PORH揭示了1型糖尿病儿童微血管自身调节功能受损。较高的灌注峰值可能反映了1型糖尿病儿童毛细血管床上游的小动脉平滑肌细胞血管收缩能力的下降。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetologia 医学-内分泌学与代谢

CiteScore

18.10

自引率

2.40%

发文量

193

审稿时长

1 months

期刊介绍： Diabetologia, the authoritative journal dedicated to diabetes research, holds high visibility through society membership, libraries, and social media. As the official journal of the European Association for the Study of Diabetes, it is ranked in the top quartile of the 2019 JCR Impact Factors in the Endocrinology & Metabolism category. The journal boasts dedicated and expert editorial teams committed to supporting authors throughout the peer review process.

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