Association of FTO polymorphisms with early age of obesity in obese Italian subjects.

Experimental Diabetes Research Pub Date : 2012-01-01 Epub Date: 2012-02-20 DOI:10.1155/2012/872176
Federica Sentinelli, Michela Incani, Federica Coccia, Danila Capoccia, Valentina Maria Cambuli, Stefano Romeo, Efisio Cossu, Maria Gisella Cavallo, Frida Leonetti, Marco Giorgio Baroni
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引用次数: 44

Abstract

Obesity is recognized as a major health problem worldwide. Genetic factors play a major role in obesity, and genomewide association studies have provided evidence that several common variants within the fat mass- and obesity-associated (FTO) gene are significantly associated with obesity. Very limited data is available on FTO in the Italian population. Aims of our study are to investigate: (1) the association of FTO gene SNPs rs9939609 and rs9930506 with body mass index (BMI) and obesity-related parameters in a large cohort (n = 752) of Italian obese subjects; (2) the association between the two FTO SNPs and age of onset of obesity. Our results demonstrate a strong association between FTO SNPs rs9939609 (P < 0.043) and rs9930506 (P < 0.029) with BMI in the Italian population. FTO rs9930506 was significantly associated with higher BMI in a G allele dose-dependent manner (BMI + 1.4 kg/m² per G allele). We also observed that the association with BMI of the two FTO variants varied with age, with the carriers of the risk alleles developing an increase in body weight earlier in life. In conclusion, our study further demonstrates a role of the genetic variability in FTO on BMI in a large Italian population.

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意大利肥胖受试者中FTO多态性与早期肥胖的关系
肥胖是世界范围内公认的主要健康问题。遗传因素在肥胖中起主要作用,全基因组关联研究已经提供证据表明,脂肪量和肥胖相关(FTO)基因中的几种常见变异与肥胖显著相关。关于意大利人口中FTO的数据非常有限。我们的研究目的是:(1)在意大利肥胖受试者的大队列(n = 752)中,FTO基因snp rs9939609和rs9930506与体重指数(BMI)和肥胖相关参数的关系;(2)两个FTO snp与肥胖发病年龄的关系。我们的研究结果表明,在意大利人群中,FTO snp rs9939609 (P < 0.043)和rs9930506 (P < 0.029)与BMI有很强的相关性。FTO rs9930506与较高的BMI呈G等位基因剂量依赖关系(BMI + 1.4 kg/m²/ G等位基因)。我们还观察到,两种FTO变异与BMI的关系随着年龄的变化而变化,风险等位基因的携带者在生命早期体重增加。总之,我们的研究进一步证明了FTO的遗传变异在意大利大量人群中对BMI的作用。
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来源期刊
Experimental Diabetes Research
Experimental Diabetes Research 医学-内分泌学与代谢
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