{"title":"Antimicrobial studies of unsymmetrical bis-1,2,3-triazoles.","authors":"Abid H Banday, Shameem A Shameem, Bashir A Ganai","doi":"10.1186/2191-2858-2-13","DOIUrl":null,"url":null,"abstract":"<p><p> Aryl azides were treated with allenylmagnesium bromide to generate 1,5-disubstituted butynyl 1,2,3-triazoles in a domino fashion, which upon Cu(I) catalyzed 1,3-dipolar cycloaddition with aryl azides afforded novel bis-1,2,3-triazoles in quantitative yields. The final products were analyzed for their antimicrobial activities against a panel of bacterial and fungal strains which revealed the products to be potent antimicrobials.</p>","PeriodicalId":19639,"journal":{"name":"Organic and Medicinal Chemistry Letters","volume":"2 ","pages":"13"},"PeriodicalIF":0.0000,"publicationDate":"2012-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/2191-2858-2-13","citationCount":"23","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Organic and Medicinal Chemistry Letters","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1186/2191-2858-2-13","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 23
Abstract
Aryl azides were treated with allenylmagnesium bromide to generate 1,5-disubstituted butynyl 1,2,3-triazoles in a domino fashion, which upon Cu(I) catalyzed 1,3-dipolar cycloaddition with aryl azides afforded novel bis-1,2,3-triazoles in quantitative yields. The final products were analyzed for their antimicrobial activities against a panel of bacterial and fungal strains which revealed the products to be potent antimicrobials.
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