The effects of green tea consumption on cardiometabolic alterations induced by experimental diabetes.

Experimental Diabetes Research Pub Date : 2012-01-01 Epub Date: 2012-02-29 DOI:10.1155/2012/309231

Patricia Fiorino, Fabiana Sant'Anna Evangelista, Fernando Santos, Fátima Maria Motter Magri, Jan Carlo Morais O B Delorenzi, Milton Ginoza, Vera Farah

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引用次数: 18

Abstract

We evaluated cardiac autonomic modulation by heart rate (HRV), and arterial pressure variability (APV), and metabolic response in streptozotocin diabetic rats treated with green tea. Male Wistar rats were separated in groups: control, drinking tap water (C), green tea-treated (GT) group, diabetic, drinking tap water (D), and diabetic, treated with green tea (DGT). Kidney mass was greater in D and DGT than in C and GT, but reduced in DGT compared to D. Green tea prevented the increase in creatinine clearance and reduced hyperglycemia in DGT compared to D. Arterial pressure was increased in GT and decreased in D compared to C. HRV was reduced in D compared with all groups. APV was decreased in D compared to C and recovery in DGT. Sympathetic modulation of APV was decreased in D compared with all groups. Green tea reduced hyperglycemia, prevented renal injury and autonomic dysfunction, suggesting reduced cardiovascular risk and target organ damage in diabetes.

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绿茶对实验性糖尿病引起的心脏代谢改变的影响。

我们通过心率(HRV)、动脉压变异性(APV)和绿茶治疗链脲佐菌素糖尿病大鼠的代谢反应来评估心脏自主调节。雄性Wistar大鼠分为对照组，饮用自来水组(C)，绿茶处理组(GT)，糖尿病组，饮用自来水组(D)，糖尿病组，绿茶处理(DGT)。与C组和GT组相比，D组和DGT组的肾体积更大，但与D组相比，DGT组的肾体积更小。绿茶阻止了DGT组肌酐清除率的增加，并降低了DGT组的高血糖。与D组相比，GT组的动脉压升高，D组的血压降低。与C相比，D组APV降低，DGT组APV恢复。与各组比较，D组APV交感调节减弱。绿茶可以降低高血糖，预防肾损伤和自主神经功能障碍，表明可以降低糖尿病患者的心血管风险和靶器官损伤。

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来源期刊

Experimental Diabetes Research 医学-内分泌学与代谢

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3-8 weeks