Endothelial dysfunction in diabetes mellitus: possible involvement of endoplasmic reticulum stress?

Experimental Diabetes Research Pub Date : 2012-01-01 Epub Date: 2012-02-28 DOI:10.1155/2012/481840
Basma Basha, Samson Mathews Samuel, Chris R Triggle, Hong Ding
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引用次数: 115

Abstract

The vascular complications of diabetes mellitus impose a huge burden on the management of this disease. The higher incidence of cardiovascular complications and the unfavorable prognosis among diabetic individuals who develop such complications have been correlated to the hyperglycemia-induced oxidative stress and associated endothelial dysfunction. Although antioxidants may be considered as effective therapeutic agents to relieve oxidative stress and protect the endothelium, recent clinical trials involving these agents have shown limited therapeutic efficacy in this regard. In the recent past experimental evidence suggest that endoplasmic reticulum (ER) stress in the endothelial cells might be an important contributor to diabetes-related vascular complications. The current paper contemplates the possibility of the involvement of ER stress in endothelial dysfunction and diabetes-associated vascular complications.

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糖尿病内皮功能障碍:可能与内质网应激有关?
糖尿病的血管并发症给该病的治疗带来了巨大的负担。糖尿病患者心血管并发症的高发生率和不良预后与高血糖诱导的氧化应激和相关的内皮功能障碍有关。虽然抗氧化剂可能被认为是缓解氧化应激和保护内皮的有效治疗药物,但最近的临床试验表明,这些药物在这方面的治疗效果有限。在最近的过去的实验证据表明内皮细胞内质网(ER)应激可能是糖尿病相关血管并发症的一个重要因素。本文考虑内质网应激参与内皮功能障碍和糖尿病相关血管并发症的可能性。
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来源期刊
Experimental Diabetes Research
Experimental Diabetes Research 医学-内分泌学与代谢
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