Serotonin and the neural processing of facial emotions in adults with autism: an fMRI study using acute tryptophan depletion.

Eileen M Daly, Quinton Deeley, Christine Ecker, Michael Craig, Brian Hallahan, Clodagh Murphy, Patrick Johnston, Debbie Spain, Nicola Gillan, Michael Brammer, Vincent Giampietro, Melissa Lamar, Lisa Page, Fiona Toal, Anthony Cleare, Simon Surguladze, Declan G M Murphy
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引用次数: 57

Abstract

Context: People with autism spectrum disorders (ASDs) have lifelong deficits in social behavior and differences in behavioral as well as neural responses to facial expressions of emotion. The biological basis to this is incompletely understood, but it may include differences in the role of neurotransmitters such as serotonin, which modulate facial emotion processing in health. While some individuals with ASD have significant differences in the serotonin system, to our knowledge, no one has investigated its role during facial emotion processing in adults with ASD and control subjects using acute tryptophan depletion (ATD) and functional magnetic resonance imaging.

Objective: To compare the effects of ATD on brain responses to primary facial expressions of emotion in men with ASD and healthy control subjects.

Design: Double-blind, placebo-controlled, crossover trial of ATD and functional magnetic resonance imaging to measure brain activity during incidental processing of disgust, fearful, happy, and sad facial expressions.

Setting: Institute of Psychiatry, King's College London, and South London and Maudsley National Health Service Foundation Trust, England.

Participants: Fourteen men of normal intelligence with autism and 14 control subjects who did not significantly differ in sex, age, or overall intelligence.

Main outcome measures: Blood oxygenation level-dependent response to facial expressions of emotion.

Results: Brain activation was differentially modulated by ATD depending on diagnostic group and emotion type within regions of the social brain network. For example, processing of disgust faces was associated with interactions in medial frontal and lingual gyri, whereas processing of happy faces was associated with interactions in middle frontal gyrus and putamen.

Conclusions: Modulation of the processing of facial expressions of emotion by serotonin significantly differs in people with ASD compared with control subjects. The differences vary with emotion type and occur in social brain regions that have been shown to be associated with group differences in serotonin synthesis/receptor or transporter density.

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血清素和自闭症成人面部情绪的神经处理:一项使用急性色氨酸耗竭的功能磁共振成像研究。
背景:自闭症谱系障碍(asd)患者在社交行为方面存在终身缺陷,在面部情绪表达的行为和神经反应方面存在差异。这种现象的生物学基础尚不完全清楚,但它可能包括神经递质(如血清素)的作用差异,血清素调节健康时的面部情绪处理。虽然一些自闭症患者血清素系统存在显著差异,但据我们所知,还没有人利用急性色氨酸耗散(ATD)和功能性磁共振成像(functional magnetic resonance imaging)研究血清素在自闭症成人和对照组面部情绪加工中的作用。目的:比较ATD对男性ASD患者与健康对照者对主要情绪面部表情的脑反应的影响。设计:双盲、安慰剂对照、ATD和功能性磁共振成像交叉试验,测量大脑在附带处理厌恶、恐惧、快乐和悲伤面部表情时的活动。环境:精神病学研究所,伦敦国王学院,南伦敦和莫兹利国家卫生服务基金会信托基金,英格兰。参与者:14名智力正常的自闭症男性和14名在性别、年龄或整体智力上没有显著差异的对照组。主要观察指标:血氧水平对情绪面部表情的依赖性反应。结果:ATD在社会脑网络区域内根据诊断组和情绪类型对脑激活的调节存在差异。例如,对厌恶面孔的处理与额叶内侧回和舌回的相互作用有关,而对快乐面孔的处理与额叶中部回和壳核的相互作用有关。结论:血清素对ASD患者面部情绪表情加工的调节作用与对照组有显著差异。这种差异因情绪类型而异,并发生在与血清素合成/受体或转运体密度的群体差异相关的大脑社交区域。
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Archives of general psychiatry
Archives of general psychiatry 医学-精神病学
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