Intravenous hypertonic saline solution (7.5%) and oral electrolytes to treat of calves with noninfectious diarrhea and metabolic acidosis.

IF 2.6 2区 农林科学 Journal of Veterinary Internal Medicine Pub Date : 2012-07-01 Epub Date: 2012-06-18 DOI:10.1111/j.1939-1676.2012.00960.x
M L R Leal, S S Fialho, F C Cyrillo, H G Bertagnon, E L Ortolani, F J Benesi
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引用次数: 20

Abstract

Objective: The aim of this study was to compare the efficacy of treating osmotic diarrhea and dehydration in calves with hypertonic saline solution (HSS) IV, isotonic electrolyte solution (IES) PO, and a combination of these 2 solutions (HSS + IES).

Experimental design: Eighteen male calves 8-30 days of age were used to evaluate the efficacy of 3 methods of fluid therapy after induction of osmotic diarrhea and dehydration. The diarrhea and dehydration were induced by administration of saccharose, spironolactone, and hydrochlorothiazide for 48 hours. The animals were randomly divided into 3 experimental groups: Group 1: 7.2% hypertonic saline solution-HSS (5 mL/kg IV); Group 2: oral isotonic electrolyte solution IES (60 mL/kg PO); or Group 3: HSS+IES. Clinical signs and laboratory finding observed 48 hours post-induction (Time 0) included diarrhea, dehydration, lethargy, and metabolic acidosis.

Results: Calves treated with HSS + IES experienced decreases in hematocrit, total protein concentration, albumin concentration, urea nitrogen concentration, and plasma volume as well as increases in blood pH, blood bicarbonate concentration, and central venous pressure between 1 and 3 hours post-treatment. These findings also were observed in animals treated with IES, however, at a slower rate than in the HSS + IES-treated animals. Animals treated with HSS continued to display signs of dehydration, lethargy, and metabolic acidosis 24 hours post-treatment.

Conclusion: Treatment with a combination of HSS and IES produced rapid and sustainable correction of hypovolemia and metabolic acidosis in calves with noninfections diarrhea and dehydration.

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静脉注射高渗生理盐水(7.5%)和口服电解质治疗犊牛非感染性腹泻和代谢性酸中毒。
目的:比较高渗生理盐水(HSS) IV、等渗电解质溶液(IES) PO以及两者联合(HSS + IES)治疗犊牛渗透性腹泻和脱水的疗效。试验设计:选用18头8 ~ 30日龄的公犊牛,对诱导渗透性腹泻和脱水后3种液体疗法的效果进行评价。给予糖、螺内酯和氢氯噻嗪48小时,引起腹泻和脱水。实验动物随机分为3个实验组:第1组:7.2%高渗生理盐水- hss (5 mL/kg IV);第二组:口服等渗电解质溶液IES (60 mL/kg PO);第3组:HSS+IES。诱导后48小时(时间0)观察到的临床体征和实验室结果包括腹泻、脱水、嗜睡和代谢性酸中毒。结果:经HSS + IES治疗的犊牛在治疗后1 ~ 3小时内,红细胞压比、总蛋白浓度、白蛋白浓度、尿素氮浓度和血浆体积下降,血pH值、血碳酸氢盐浓度和中心静脉压升高。然而,在接受IES治疗的动物中也观察到这些发现,其速度比HSS + IES治疗的动物慢。用HSS治疗的动物在治疗24小时后继续表现出脱水、嗜睡和代谢性酸中毒的迹象。结论:HSS和IES联合治疗可以快速持续地纠正犊牛低血容量和代谢性酸中毒,并伴有非感染性腹泻和脱水。
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来源期刊
Journal of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine Veterinary-General Veterinary
自引率
11.50%
发文量
243
期刊介绍: The mission of the Journal of Veterinary Internal Medicine is to advance veterinary medical knowledge and improve the lives of animals by publication of authoritative scientific articles of animal diseases.
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