p16 overexpression in malignant and premalignant lesions of the oral and esophageal mucosa following allogeneic hematopoietic stem cell transplantation.

Head and Neck Optical Diagnostics Society Pub Date : 2012-06-23 DOI:10.1186/1758-3284-4-38

Yasumasa Kakei, Masaya Akashi, Hideki Komatsubara, Tsutomu Minamikawa, Takahide Komori

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引用次数: 6

Abstract

Objectives: Secondary malignancy in the oral mucosa is recognized as one of the most serious complications in patients who received allogenic hematopoietic stem cell transplantation (HSCT). However, potential risk factors associated with carcinogenesis after HSCT that have been reported remain elusive. We experienced a rare case of secondary malignancies of the oral and esophageal mucosa and analyzed the expression of tumor suppressor gene product p16.

Case report: A 35-year-old male had malignant lesions of the oral and esophageal mucosa two years after HSCT. Partial maxillectomy and endoscopic submucosal dissection were performed. Immunohistochemical analyses revealed that the tumor cells of malignant and premalignant lesions of the oral cavity and esophagus but not keratosis were positive for p16.

Conclusions: Pathological examinations with p16 immunohistochemistry may contribute to an early diagnosis of secondary malignancy after HSCT.

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P16在异基因造血干细胞移植后口腔和食管黏膜恶性和癌前病变中的过表达。

目的:口腔黏膜继发性恶性肿瘤是接受同种异体造血干细胞移植(HSCT)患者最严重的并发症之一。然而，与HSCT后癌变相关的潜在危险因素仍未被报道。我们报告了一例罕见的口腔和食管黏膜继发性恶性肿瘤，并分析了肿瘤抑制基因产物p16的表达。病例报告:一名35岁男性，经HSCT术后2年出现口腔及食管黏膜恶性病变。行上颌部分切除术和内镜下粘膜夹层。免疫组化分析显示，口腔和食管恶性及癌前病变的肿瘤细胞中p16阳性，而角化病的肿瘤细胞中p16阳性。结论:病理检查p16免疫组化可能有助于HSCT后继发性恶性肿瘤的早期诊断。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Head and Neck Optical Diagnostics Society

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