Patrick F Sullivan, Cecilia Magnusson, Abraham Reichenberg, Marcus Boman, Christina Dalman, Michael Davidson, Eyal Fruchter, Christina M Hultman, Michael Lundberg, Niklas Långström, Mark Weiser, Anna C Svensson, Paul Lichtenstein
{"title":"Family history of schizophrenia and bipolar disorder as risk factors for autism.","authors":"Patrick F Sullivan, Cecilia Magnusson, Abraham Reichenberg, Marcus Boman, Christina Dalman, Michael Davidson, Eyal Fruchter, Christina M Hultman, Michael Lundberg, Niklas Långström, Mark Weiser, Anna C Svensson, Paul Lichtenstein","doi":"10.1001/archgenpsychiatry.2012.730","DOIUrl":null,"url":null,"abstract":"<p><strong>Context: </strong>The clinical and etiologic relation between autism spectrum disorders (ASDs) and schizophrenia is unclear. The degree to which these disorders share a basis in etiology has important implications for clinicians, researchers, and those affected by the disorders.</p><p><strong>Objective: </strong>To determine whether a family history of schizophrenia and/or bipolar disorder is a risk factor for ASD.</p><p><strong>Design, setting, and participants: </strong>We conducted a case-control evaluation of histories of schizophrenia or bipolar disorder in first-degree relatives of probands in 3 samples—population registers in Sweden, Stockholm County (in Sweden), and Israel. Probands met criteria for ASD, and affection status of parents and siblings for schizophrenia and bipolar disorder were established.</p><p><strong>Results: </strong>The presence of schizophrenia in parents was associated with an increased risk for ASD in a Swedish national cohort (odds ratio [OR], 2.9; 95% CI, 2.5-3.4) and a Stockholm County cohort (OR, 2.9; 95% CI, 2.0-4.1). Similarly, schizophrenia in a sibling was associated with an increased risk for ASD in a Swedish national cohort (OR, 2.6; 95% CI, 2.0-3.2) and an Israeli conscription cohort (OR, 12.1; 95% CI, 4.5-32.0). Bipolar disorder showed a similar pattern of associations but of lesser magnitude.</p><p><strong>Conclusions: </strong>Findings from these 3 registers along with consistent findings from a similar study in Denmark suggest that ASD, schizophrenia, and bipolar disorder share common etiologic factors.</p>","PeriodicalId":8286,"journal":{"name":"Archives of general psychiatry","volume":"69 11","pages":"1099-1103"},"PeriodicalIF":0.0000,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4187103/pdf/nihms632373.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archives of general psychiatry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1001/archgenpsychiatry.2012.730","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Context: The clinical and etiologic relation between autism spectrum disorders (ASDs) and schizophrenia is unclear. The degree to which these disorders share a basis in etiology has important implications for clinicians, researchers, and those affected by the disorders.
Objective: To determine whether a family history of schizophrenia and/or bipolar disorder is a risk factor for ASD.
Design, setting, and participants: We conducted a case-control evaluation of histories of schizophrenia or bipolar disorder in first-degree relatives of probands in 3 samples—population registers in Sweden, Stockholm County (in Sweden), and Israel. Probands met criteria for ASD, and affection status of parents and siblings for schizophrenia and bipolar disorder were established.
Results: The presence of schizophrenia in parents was associated with an increased risk for ASD in a Swedish national cohort (odds ratio [OR], 2.9; 95% CI, 2.5-3.4) and a Stockholm County cohort (OR, 2.9; 95% CI, 2.0-4.1). Similarly, schizophrenia in a sibling was associated with an increased risk for ASD in a Swedish national cohort (OR, 2.6; 95% CI, 2.0-3.2) and an Israeli conscription cohort (OR, 12.1; 95% CI, 4.5-32.0). Bipolar disorder showed a similar pattern of associations but of lesser magnitude.
Conclusions: Findings from these 3 registers along with consistent findings from a similar study in Denmark suggest that ASD, schizophrenia, and bipolar disorder share common etiologic factors.