Bone: incretin hormones perceiver or receiver?

Experimental Diabetes Research Pub Date : 2012-01-01 Epub Date: 2012-06-17 DOI:10.1155/2012/519784
Ilaria Dicembrini, Edoardo Mannucci, Carlo Maria Rotella
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引用次数: 25

Abstract

Novel incretin-based drugs, such as glucagon-like peptide-1 receptor agonists (GLP-1 RA) and dipeptidyl peptidase-4 inhibitors (DPP-4i), have been last introduced in the pharmacological treatment of type 2 diabetes. In the last few years, the interest on the relationship of gut hormones with bone metabolism in diabetes has been increasing. The aim of present paper is to examine in vitro and in vivo evidence on the connections between incretin hormones and bone metabolism. We also discuss results of clinical trials and metaanalysis, explore the effects of incretin drugs in vitro on osteogenic cells and osteoclasts, and speculate on the possibility of different effects of GLP-1 RA and DPP-4i on the risk of bone fractures risk in humans. Although existing preliminary evidence suggests a protective effect on the bone, at least for DPP-4i, further controlled, long-term studies with measurement of bone markers, bone density, and clinical fractures rates are needed to substantiate and confirm those findings.

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骨:肠促胰岛素激素的感知者还是接受者?
新型肠促胰岛素类药物,如胰高血糖素样肽-1受体激动剂(GLP-1 RA)和二肽基肽酶-4抑制剂(DPP-4i),最近被引入到2型糖尿病的药物治疗中。近年来,人们对肠道激素与糖尿病患者骨代谢关系的研究日益关注。本文旨在探讨肠促胰岛素激素与骨代谢之间的联系的体外和体内证据。我们还讨论了临床试验和荟萃分析的结果,探讨了体外肠促胰岛素药物对成骨细胞和破骨细胞的影响,并推测了GLP-1 RA和DPP-4i对人类骨折风险的不同影响的可能性。尽管现有的初步证据表明DPP-4i对骨骼有保护作用,至少对DPP-4i有保护作用,但需要进一步的对照、长期研究,测量骨骼标志物、骨密度和临床骨折率,以证实和确认这些发现。
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来源期刊
Experimental Diabetes Research
Experimental Diabetes Research 医学-内分泌学与代谢
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3-8 weeks
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