Protective effects of salivary factors in dental caries in diabetic patients of Pakistan.

Experimental Diabetes Research Pub Date : 2012-01-01 Epub Date: 2012-06-24 DOI:10.1155/2012/947304
Muhammad Jawed, Rashid N Khan, Syed M Shahid, Abid Azhar
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Abstract

Salivary factors have been studied for their effects on the process of dental caries in patients of diabetes mellitus type 2. In this study, protective role of salivary pH, salivary flow rate, and salivary calcium is assessed in the patients of diabetes mellitus type 2 with dental caries. The samples of saliva were collected from 400 patients of diabetes mellitus type 2 and 300 age- and sex- matched controls after getting informed consent. All the subjects were classified into four groups according to age. The severity of dental caries was counted by decayed, missed, and filled teeth (DMFT) score. The salivary pH, flow rate, and calcium levels were found to be low in patients as compared to controls. The levels of fasting blood sugar, HbA1c, and DMFT score were found to be significantly high in patients than controls. The glycemic factors were significantly correlated with salivary factors indicating their influence on progression of caries in diabetes. On the basis of findings, it is concluded that the suitable salivary pH and flow rate may be regarded as main protective factors against dental caries in diabetes. Optimum level of salivary calcium may be responsible for continuous supply of calcium to arrest the demineralization and help reduce the occurrence of dental caries.

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唾液因素对巴基斯坦糖尿病患者龋齿的保护作用。
人们研究了唾液因素对 2 型糖尿病患者龋齿过程的影响。本研究评估了唾液 pH 值、唾液流速和唾液钙对 2 型糖尿病龋齿患者的保护作用。在获得知情同意后,研究人员收集了 400 名 2 型糖尿病患者和 300 名年龄和性别匹配的对照组患者的唾液样本。所有受试者按年龄分为四组。龋齿的严重程度以蛀牙、缺失牙和填充牙(DMFT)评分来计算。与对照组相比,发现患者的唾液 pH 值、流速和钙水平较低。发现患者的空腹血糖、HbA1c 和 DMFT 评分明显高于对照组。血糖因子与唾液因子有明显的相关性,表明它们对糖尿病患者龋齿的发展有影响。根据研究结果得出结论,适当的唾液 pH 值和流速可被视为糖尿病患者预防龋齿的主要保护因素。唾液钙的最佳水平可持续供应钙质,阻止脱钙,帮助减少龋齿的发生。
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来源期刊
Experimental Diabetes Research
Experimental Diabetes Research 医学-内分泌学与代谢
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3-8 weeks
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