CIP2A is highly expressed in hepatocellular carcinoma and predicts poor prognosis.

Diagnostic Molecular Pathology Pub Date : 2012-09-01 DOI:10.1097/PDM.0b013e318249fd8b

Hui He, Gang Wu, Weijie Li, Yuecheng Cao, Yongfeng Liu

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引用次数: 47

Abstract

Background: Cancerous inhibitor of protein phosphatase 2A (CIP2A) is highly expressed in hepatocellular carcinoma (HCC) and promotes cell proliferation, cell invasion, and aggressive tumor behavior. However, there have been few studies on the usefulness of CIP2A as an independent prognostic index of HCC. In the current study, the aim was to explore the association between CIP2A expression and prognosis in HCC.

Methods: The expression of CIP2A and c-MYC was examined by immunohistochemistry in 136 HCC specimens. CIP2A mRNA expression in 27 HCC tissues was also analyzed using quantitative reverse-transcription polymerase chain reaction. The prognostic significance was analyzed by the Kaplan-Meier survival method and log-rank test. Cox regression was adopted for univariate and multivariate analysis of prognostic factors.

Results: CIP2A protein was found to be highly expressed in human liver cancer samples (85/136, 62.5%) and correlated with poor survival (P<0.05). The liver cancer tissues examined exhibited much higher levels of CIP2A mRNA compared with their corresponding normal tissues (19/27, 70.3%). Furthermore, CIP2A mRNA levels were correlated with c-MYC mRNA levels. In addition, the highly expressed CIP2A was associated with recurrence (P=0.014) and invasion (P=0.017) of HCC. Patients with high CIP2A expression had both poorer overall survival (OS) and disease-free survival (DFS). On multivariate analysis, the CIP2A status was a significant prognostic factor for OS and DFS (P=0.017, P=0.026, respectively).

Conclusions: CIP2A overexpression may be useful as an independent prognostic biomarker for OS and DFS of HCC.

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CIP2A在肝细胞癌中高表达，预示预后不良。

背景:蛋白磷酸酶2A癌性抑制剂(CIP2A)在肝细胞癌(HCC)中高表达，促进细胞增殖、细胞侵袭和肿瘤侵袭行为。然而，关于CIP2A作为HCC独立预后指标的有效性的研究很少。本研究旨在探讨HCC中CIP2A表达与预后的关系。方法:应用免疫组化方法检测136例肝癌组织中CIP2A和c-MYC的表达。用定量逆转录聚合酶链反应分析了27例HCC组织中CIP2A mRNA的表达。采用Kaplan-Meier生存法和log-rank检验分析预后意义。采用Cox回归对预后因素进行单因素和多因素分析。结果:CIP2A蛋白在人肝癌样本中高表达(85/136,62.5%)，且与较差的生存率相关(结论:CIP2A过表达可能可作为肝癌OS和DFS的独立预后生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Diagnostic Molecular Pathology 医学-病理学

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>12 weeks

期刊介绍： Diagnostic Molecular Pathology focuses on providing clinical and academic pathologists with coverage of the latest molecular technologies, timely reviews of established techniques, and papers on the applications of these methods to all aspects of surgical pathology and laboratory medicine. It publishes original, peer-reviewed contributions on molecular probes for diagnosis, such as tumor suppressor genes, oncogenes, the polymerase chain reaction (PCR), and in situ hybridization. Articles demonstrate how these highly sensitive techniques can be applied for more accurate diagnosis.

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